Nitrate-rich beet juice intake on cardiovascular performance in response to exercise in postmenopausal women with arterial hypertension: study protocol for a randomized controlled trial

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorBenjamim, Cicero Jonas R.-
Autor(es): dc.creatorSousa, Yaritza Brito Alves-
Autor(es): dc.creatorPorto, Andrey Alves-
Autor(es): dc.creatorde Moraes Pontes, Yasmim Mota-
Autor(es): dc.creatorTavares, Simone Sakagute-
Autor(es): dc.creatorda Silva Rodrigues, Guilherme-
Autor(es): dc.creatorda Silva, Leonardo Santos Lopes-
Autor(es): dc.creatorda Silva Goncalves, Leonardo-
Autor(es): dc.creatorGuimaraes, Carolina Scoqui-
Autor(es): dc.creatorRebelo, Macário Arosti-
Autor(es): dc.creatorda Silva Sobrinho, Andressa Crystine-
Autor(es): dc.creatorTanus-Santos, Jose E.-
Autor(es): dc.creatorValenti, Vitor Engracia-
Autor(es): dc.creatorGualano, Bruno-
Autor(es): dc.creatorBueno Júnior, Carlos Roberto-
Data de aceite: dc.date.accessioned2025-08-21T15:26:08Z-
Data de disponibilização: dc.date.available2025-08-21T15:26:08Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/s13063-023-07117-2-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249035-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249035-
Descrição: dc.descriptionBackground: There is no evidence of the use of beetroot juice with a previously recommended dose of nitrate (NO3) (> 300 mg) on the cardiovascular performance during and recovery following exercise in postmenopausal women with systemic arterial hypertension (SAH). Methods: We will investigate the effects of beetroot juice rich in NO3 acutely (800 mg) and during a week with daily doses (400 mg) on blood pressure, heart rate (HR), cardiac autonomic control, endothelial function, inflammatory, hormonal, and stress biomarkers oxidative stress and enzymes involved in nitric oxide synthesis and mitochondrial regulation, under resting conditions, as well as mediated by submaximal aerobic exercise sessions. Through a randomized, crossover, triple-blind, placebo-controlled clinical trial, 25 physically inactive women with SAH will undergo an acute and 1-week trial, each with two intervention protocols: (1) placebo and (2) beetroot, in which will ingest beet juice with or without NO3 in its composition with a 7-day washout interval. On collection days, exercise will be performed on a treadmill for 40 min at a speed corresponding to 65–70% of VO2peak. The collection of variables (cardiovascular, autonomic, and blood samples for molecular analyses) of the study will take place at rest (135 min after ingestion of the intervention), during exercise (40 min), and in the effort recovery stage (during 60 min) based on previously validated protocols. The collections were arranged so that the measurement of one variable does not interfere with the other and that they have adequate intervals between them. Discussion: The results of this research may help in the real understanding of the nutritional compounds capable of generating safety to the cardiovascular system during physical exercise, especially for women who are aging and who have cardiovascular limitations (e.g., arterial hypertension) to perform physical exercise. Therefore, our results will be able to help specific nutritional recommendations to optimize cardiovascular health. Trial registration: ClinicalTrials.gov NCT05384340. Registered on May 20, 2022.-
Descrição: dc.descriptionDepartment of Internal Medicine Ribeirão Preto Medical School University of São Paulo, SP-
Descrição: dc.descriptionRibeirao Preto Nursing School University of São Paulo, SP-
Descrição: dc.descriptionMovement Sciences Autonomic Nervous System Center (CESNA) São Paulo State University (UNESP), SP-
Descrição: dc.descriptionRibeirao Preto School of Physical Education and Sports University of São Paulo, SP-
Descrição: dc.descriptionDepartment of Pharmacology Faculty of Medical Sciences State University of Campinas, SP-
Descrição: dc.descriptionDepartment of Pharmacology Ribeirão Preto Medical School University of São Paulo, SP-
Descrição: dc.descriptionAutonomic Nervous System Center (CESNA) São Paulo State University (UNESP), SP-
Descrição: dc.descriptionApplied Physiology & Nutrition Research Group University of São Paulo Medical School (FMUSP), SP-
Descrição: dc.descriptionMovement Sciences Autonomic Nervous System Center (CESNA) São Paulo State University (UNESP), SP-
Descrição: dc.descriptionAutonomic Nervous System Center (CESNA) São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationTrials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBeta vulgaris-
Palavras-chave: dc.subjectCardiovascular physiological phenomena-
Palavras-chave: dc.subjectHypertension-
Palavras-chave: dc.subjectNitrate-
Palavras-chave: dc.subjectPost-menopause-
Palavras-chave: dc.subjectSports nutritional sciences-
Título: dc.titleNitrate-rich beet juice intake on cardiovascular performance in response to exercise in postmenopausal women with arterial hypertension: study protocol for a randomized controlled trial-
Tipo de arquivo: dc.typelivro digital-
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