Roles of Bothrops jararacussu toxins I and II: Antiviral findings against Zika virus

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorOswaldo Cruz Foundation (Fiocruz)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorCassani, Natasha Marques-
Autor(es): dc.creatorSantos, Igor Andrade-
Autor(es): dc.creatorGrosche, Victória Riquena-
Autor(es): dc.creatorFerreira, Giulia Magalhães-
Autor(es): dc.creatorGuevara-Vega, Marco-
Autor(es): dc.creatorRosa, Rafael Borges-
Autor(es): dc.creatorPena, Lindomar José-
Autor(es): dc.creatorNicolau-Junior, Nilson-
Autor(es): dc.creatorCintra, Adélia Cristina Oliveira-
Autor(es): dc.creatorMineo, Tiago Patriarca-
Autor(es): dc.creatorSabino-Silva, Robinson-
Autor(es): dc.creatorSampaio, Suely Vilela-
Autor(es): dc.creatorJardim, Ana Carolina Gomes-
Data de aceite: dc.date.accessioned2025-08-21T17:13:00Z-
Data de disponibilização: dc.date.available2025-08-21T17:13:00Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2022.12.102-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249020-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249020-
Descrição: dc.descriptionZika virus is the etiologic agent of Zika fever, and has been previously associated with cases of microcephaly, drawing the attention of the health authorities worldwide. However, no vaccine or antiviral are currently available. Phospholipases A2 (PLA2) isolated from snake venoms have demonstrated antiviral activity against several viruses. Here we demonstrated the anti-ZIKV activity of bothropstoxins-I and II (BthTX-I and II) isolated from Bothrops jararacussu venom. Vero E6 cells were infected with ZIKVPE243 in the presence of compounds for 72 h, when virus titers were evaluated. BthTX-I and II presented strong dose-dependent inhibition of ZIKV, with a SI of 149.1 and 1.44 × 105, respectively. These toxins mainly inhibited the early stages of the replicative cycle, such as during the entry of ZIKV into host cells, as shown by the potent virucidal effect, suggesting the action of these toxins on the virus particles. Moreover, BthTX-I and II presented significant activity towards post-entry stages of the ZIKV replicative cycle. Molecular docking analyses showed that BthTX-I and II potentially interact with DII and DIII domains from ZIKV Envelope protein. Our findings show that these PLA2s could be used as useful templates for the development of future antiviral candidate drugs against Zika fever.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
Descrição: dc.descriptionInstitute of Biomedical Science (ICBIM) Federal University of Uberlândia (UFU), Minas Gerais-
Descrição: dc.descriptionof Biosciences Humanities and Exact Sciences (Ibilce) São Paulo State University (Unesp), SP-
Descrição: dc.descriptionRodents Animal Facilities Complex Federal University of Uberlândia, Minas Gerais-
Descrição: dc.descriptionDepartment of Virology Aggeu Magalhães Institute (IAM) Oswaldo Cruz Foundation (Fiocruz)-
Descrição: dc.descriptionInstitute of Biotechnology Federal University of Uberlândia (UFU), Minas Gerais-
Descrição: dc.descriptionDepartment of Clinical Analyses Toxicology and Food Sciences School of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo – USP, SP-
Descrição: dc.descriptionof Biosciences Humanities and Exact Sciences (Ibilce) São Paulo State University (Unesp), SP-
Descrição: dc.descriptionCNPq: 133956/2020-2-
Descrição: dc.descriptionCNPq: 142495/2020-4-
Descrição: dc.descriptionCAPES: 88881.506794/2020-01-
Descrição: dc.descriptionFAPEMIG: APQ-01487-22-
Formato: dc.format630-640-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Biological Macromolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntiviral drugs-
Palavras-chave: dc.subjectToxins-
Palavras-chave: dc.subjectZika virus-
Título: dc.titleRoles of Bothrops jararacussu toxins I and II: Antiviral findings against Zika virus-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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