Latex–collagen membrane: an alternative treatment for tibial bone defects

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorTerasaki Institute for Biomedical Innovation-
Autor(es): dc.contributorImperial College London-
Autor(es): dc.contributorUniversity Center of Hermínio Ometto Foundation (FHO)-
Autor(es): dc.contributorCalifornia State University-
Autor(es): dc.creatorde Paiva, Marcela Britto-
Autor(es): dc.creatorPegorin Brasil, Giovana Sant’Ana-
Autor(es): dc.creatorChagas, Ana Laura Destro-
Autor(es): dc.creatorMacedo, Ana Paula-
Autor(es): dc.creatorRamos, Júnia-
Autor(es): dc.creatorIssa, João Paulo Mardegan-
Autor(es): dc.creatorGangrade, Ankit-
Autor(es): dc.creatorFloriano, Juliana Ferreira-
Autor(es): dc.creatorCaetano, Guilherme Ferreira-
Autor(es): dc.creatorLi, Bingbing-
Autor(es): dc.creatorFarhadi, Neda-
Autor(es): dc.creatorMandal, Kalpana-
Autor(es): dc.creatorDokmeci, Mehmet Remzi-
Autor(es): dc.creatorJucaud, Vadim-
Autor(es): dc.creatorHerculano, Rondinelli Donizetti-
Autor(es): dc.creatorShimano, Antonio Carlos-
Data de aceite: dc.date.accessioned2025-08-21T17:18:36Z-
Data de disponibilização: dc.date.available2025-08-21T17:18:36Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10853-022-08009-7-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249012-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249012-
Descrição: dc.descriptionDue to the difficulty of consolidation, the risk of fractures, and the high cost of therapy, the orthopedic field views the restoration of bony defects or post-traumatic diseases as a significant issue. In recent years, efforts have been made toward guided bone regeneration as a viable solution. In this study, natural rubber latex (NRL) and latex–collagen (NRL-COL) membranes were developed and characterized, and their effects on bone regeneration in rat tibial lesions were assessed. According to the physicochemical findings, the hydrolyzed COL was effectively incorporated into the NRL membrane to produce a more robust membrane (348% increase in stress) and showed good biocompatibility for human dermal fibroblast cells and in hemolytic activity assay. According to bone analysis using computed microtomography, a substantial difference in bone volume (BV) was found among NRL, control (CONT), and NRL-COL. NRL-COL exhibited the greatest value for the bone volume/total volume ratio (BV/TV). The presence of NRL and COL was significant for the analysis of BV and BV/TV, respectively. All the experimental groups demonstrated a higher bone quality and fracture resistance, as shown by the mechanical properties of the bone. In the COL group, both neoformation of bone and total collagen levels were greater, indicating that treated defects had been closed and mature bone cells were present. Due to its angiogenic properties and the low cost of NRL membrane production, the NRL-COL membrane could be a good substitute for upcoming bone regeneration applications. Graphical Abstract: [Figure not available: see fulltext.]-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFoundation for the National Institutes of Health-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionBioengineering Laboratory Ribeirão Preto Medical School São Paulo University (USP), SP-
Descrição: dc.descriptionDepartment of Biotechnology and Bioprocess Engineering School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthesis School of Dentistry of Ribeirão Preto São Paulo University (USP), SP-
Descrição: dc.descriptionDepartment of Morphology Physiology and Basic Pathology School of Dentistry of Ribeirão Preto São Paulo University (USP), SP-
Descrição: dc.descriptionTerasaki Institute for Biomedical Innovation-
Descrição: dc.descriptionBotucatu Medical School São Paulo State University (UNESP), SP-
Descrição: dc.descriptionNational Heart and Lung Institute Imperial College London-
Descrição: dc.descriptionUniversity Center of Hermínio Ometto Foundation (FHO), SP-
Descrição: dc.descriptionDivision of Dermatology Department of Internal Medicine Ribeirão Preto Medical School São Paulo University (USP), SP-
Descrição: dc.descriptionAutonomy Research Center for STEAHM (ARCS) California State University-
Descrição: dc.descriptionDepartment of Biotechnology and Bioprocess Engineering School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionBotucatu Medical School São Paulo State University (UNESP), SP-
Descrição: dc.descriptionCAPES: 1713685-
Descrição: dc.descriptionFoundation for the National Institutes of Health: 1R01GM126571-01-
Descrição: dc.descriptionFoundation for the National Institutes of Health: 1U01CA214411-01A1-
Descrição: dc.descriptionFAPESP: 2011/17411-8-
Descrição: dc.descriptionFAPESP: 2014/17526-8)-
Descrição: dc.descriptionFAPESP: 2017/19603-8-
Descrição: dc.descriptionFAPESP: 2017/20051-0-
Descrição: dc.descriptionCNPq: 317203/2021-5-
Formato: dc.format22019-22041-
Idioma: dc.languageen-
Relação: dc.relationJournal of Materials Science-
???dc.source???: dc.sourceScopus-
Título: dc.titleLatex–collagen membrane: an alternative treatment for tibial bone defects-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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