Comparative study between apocynin and protocatechuic acid regarding antioxidant capacity and vascular effects

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFaculdades de Dracena (UNIFADRA)-
Autor(es): dc.contributorUniversidade Estadual de Maringá (UEM)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorVanderbilt University-
Autor(es): dc.creatorGraton, Murilo E.-
Autor(es): dc.creatorFerreira, Bruno H. S. H.-
Autor(es): dc.creatorTroiano, Jéssica A.-
Autor(es): dc.creatorPotje, Simone R.-
Autor(es): dc.creatorVale, Gabriel T.-
Autor(es): dc.creatorNakamune, Ana Cláudia M. S.-
Autor(es): dc.creatorTirapelli, Carlos R.-
Autor(es): dc.creatorMiller, Francis J.-
Autor(es): dc.creatorXimenes, Valdecir F.-
Autor(es): dc.creatorAntoniali, Cristina-
Data de aceite: dc.date.accessioned2025-08-21T16:18:10Z-
Data de disponibilização: dc.date.available2025-08-21T16:18:10Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-11-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fphys.2022.1047916-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249010-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249010-
Descrição: dc.descriptionReactive oxygen species (ROS) derived from NOX enzymes activity play an important role in the development of cardiovascular diseases. Compounds able to decrease oxidative stress damage are potential candidates as drugs and/or supplements for hypertension treatment. Here, we aimed to compare in vitro ROS scavenging potency, effective NOX inhibition and effects on vascular reactivity of apocynin to another phenolic compound, protocatechuic acid, in vascular cells from spontaneously hypertensive rat (SHR), where redox signaling is altered and contributes to the development and/or maintenance of hypertension. We evaluated the in vitro antioxidant capacity and free radical scavenging capacity of both phenolic compounds. Moreover, we investigated the effect of both compounds on lipid peroxidation, lucigenin chemiluminescence, nitric oxide (NO•) levels and ROS concentration in vascular cells of SHR or human umbilical vein endothelial cell (HUVEC). Apocynin and protocatechuic acid presented antioxidant capacity and ability as free radical scavengers, decreased thiobarbituric acid reactive substances (TBARS) in aortic cells from SHR, and increased NO• concentration in isolated HUVEC. Both compounds were able to reduce lucigenin chemiluminescence and increased the potency of acetylcholine in aorta of SHR. However, in SHR aortas, only apocynin diminished the contraction induced by phenylephrine. In conclusion, these results strongly reinforce the potential application of substances such as apocynin and protocatechuic acid that combine abilities as scavenging and/or prevention of ROS generation, establishment of NO bioactivity and modulation of vascular reactivity. Due to its phytochemical origin and low toxicity, its potential therapeutic use in vascular diseases should be considered.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionNational Institute of Standards and Technology-
Descrição: dc.descriptionPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas SBFis São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Support Production and Animal Health School of Veterinary Medicine São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionFundação Dracenense de Educação e Cultura (FUNDEC) Faculdades de Dracena (UNIFADRA)-
Descrição: dc.descriptionDepartment of Biosciences Minas Gerais State University (UEMG), Minas Gerais-
Descrição: dc.descriptionDepartment of Psychiatry Nursing and Human Sciences College of Nursing of Ribeirão Preto University of São Paulo (USP), São Paulo-
Descrição: dc.descriptionNashville VA Medical Center Vanderbilt University-
Descrição: dc.descriptionDepartment of Chemistry Faculty of Sciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas SBFis São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Support Production and Animal Health School of Veterinary Medicine São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Chemistry Faculty of Sciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionFAPESP: 2016/22180-9 2016/01476-7 2017/18436-0-
Descrição: dc.descriptionCNPq: 302526/2016-1-
Descrição: dc.descriptionNational Institute of Standards and Technology: 465637/2014-0 2014/50926-0-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectapocynin-
Palavras-chave: dc.subjectnitric oxide-
Palavras-chave: dc.subjectoxidative stress-
Palavras-chave: dc.subjectprotocatechuic acid-
Palavras-chave: dc.subjectreactive oxygen species-
Título: dc.titleComparative study between apocynin and protocatechuic acid regarding antioxidant capacity and vascular effects-
Tipo de arquivo: dc.typelivro digital-
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