Proteoglycans orchestrate remodeling of prostatic cytoarchitecture after androgenic blockade in old gerbils

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorSão José Rio Preto School of Medicine (FAMERP)-
Autor(es): dc.creatorCampos, Silvana G. P.-
Autor(es): dc.creatorGonçalves, Bianca F.-
Autor(es): dc.creatorRuiz, Thalles Fernando Rocha-
Autor(es): dc.creatorLeonel, Ellen Cristina R.-
Autor(es): dc.creatorRibeiro, Daniele L.-
Autor(es): dc.creatorFalleiros Junior, Luiz Roberto-
Autor(es): dc.creatorGoes, Rejane M.-
Autor(es): dc.creatorTaboga, Sebastião R.-
Data de aceite: dc.date.accessioned2025-08-21T18:09:21Z-
Data de disponibilização: dc.date.available2025-08-21T18:09:21Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/pros.24451-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248993-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248993-
Descrição: dc.descriptionBackground: The aim of this study was to evaluate modifications in proteoglycan morphology and composition in the prostatic stroma of 18-month-old gerbils after surgical castration, in association or not with an androgenic blockade. Methods: The animals (n = 5) were sorted into groups subjected or not to antiandrogen treatment (flutamide 10 mg/kg/day) administered for the total postsurgery period and euthanized at 7- or 30-day postcastration; the control group consisted of intact animals. Tissue analysis included immunohistochemical assessment (perlecan and chondroitin sulfate) and proteoglycan morphology was analyzed by transmission electron microscopy. Results: Chondroitin sulfate frequency was increased 7 days postcastration with an androgenic blockade. The presence of these carbohydrates was rare after 30 days of androgenic blockade treatment. There was a significant increase in the amount of perlecan in the prostate stroma from groups subjected to castration plus flutamide for 7 or 30 days. Ultrastructural analysis showed that the incidence of areas occupied by proteoglycans and basement membrane was altered by treatment. In addition, androgenic blockade results in changes in the amount, thickness, and morphology of these structures. At 30 days postcastration, with or without flutamide treatment, larger proteoglycans were common. Conclusions: In this study, in particular, the decrease in chondroitin sulfate after the longer period might be understood as a prostatic response to androgenic deprivation, while the high frequency and permanence of perlecan led to the assumption that its modulation could be androgen-independent. Length and form alterations in proteoglycans as well as associations among them and with the basement membrane were dynamic events in the prostate microenvironment.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Biological Sciences Institute of Biosciences Humanities and Exact Sciences São Paulo State University (Unesp), São Paulo-
Descrição: dc.descriptionDepartment of Structural and Functional Biology State University of Campinas (UNICAMP), São Paulo-
Descrição: dc.descriptionDepartment of Histology Embryology and Cell Biology Institute of Biological Sciences Federal University of Goiás (UFG), Goiás-
Descrição: dc.descriptionDepartment of Cell Biology Histology and Embriology Institute of Biomedical Sciences-ICBIM Federal University of Uberlândia (UFU), Minas Gerais-
Descrição: dc.descriptionDepartment of Urology São José Rio Preto School of Medicine (FAMERP), São Paulo-
Descrição: dc.descriptionDepartment of Biological Sciences Institute of Biosciences Humanities and Exact Sciences São Paulo State University (Unesp), São Paulo-
Formato: dc.format179-189-
Idioma: dc.languageen-
Relação: dc.relationProstate-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcastration-
Palavras-chave: dc.subjectchondroitin sulfate-
Palavras-chave: dc.subjectflutamide-
Palavras-chave: dc.subjectperlecan-
Palavras-chave: dc.subjectprostate-
Título: dc.titleProteoglycans orchestrate remodeling of prostatic cytoarchitecture after androgenic blockade in old gerbils-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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