Follow-up of young adult monozygotic twins after simultaneous critical coronavirus disease 2019: A case report

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorInstituto de Investigação em Imunologia—Instituto Nacional de Ciências e Tecnologia-iii-INCT-
Autor(es): dc.creatorde Castro, Mateus V.-
Autor(es): dc.creatorSilva, Monize V. R.-
Autor(es): dc.creatorSoares, Flávia B.-
Autor(es): dc.creatorCória, Vivian R.-
Autor(es): dc.creatorNaslavsky, Michel S.-
Autor(es): dc.creatorScliar, Marilia O.-
Autor(es): dc.creatorCastelli, Erick C.-
Autor(es): dc.creatorde Oliveira, Jamile R.-
Autor(es): dc.creatorSasahara, Greyce L.-
Autor(es): dc.creatorSantos, Keity S.-
Autor(es): dc.creatorCunha-Neto, Edecio-
Autor(es): dc.creatorKalil, Jorge-
Autor(es): dc.creatorZatz, Mayana-
Data de aceite: dc.date.accessioned2025-08-21T19:17:59Z-
Data de disponibilização: dc.date.available2025-08-21T19:17:59Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-09-29-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fmed.2022.1008585-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248991-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248991-
Descrição: dc.descriptionBackground: The influence of the host genome on coronavirus disease 2019 (COVID-19) susceptibility and severity is supported by reports on monozygotic (MZ) twins where both were infected simultaneously with similar disease outcomes, including several who died due to the SARS-CoV-2 infection within days apart. However, successive exposures to pathogens throughout life along with other environmental factors make the immune response unique for each individual, even among MZ twins. Case presentation and methods: Here we report a case of a young adult monozygotic twin pair, who caught attention since both presented simultaneously severe COVID-19 with the need for oxygen support despite age and good health conditions. One of the twins, who spent more time hospitalized, reported symptoms of long-COVID even 7 months after infection. Immune cell profile and specific responses to SARS-CoV-2 were evaluated as well as whole exome sequencing. Conclusion: Although the MZ twin brothers shared the same genetic mutations which may be associated with their increased risk of developing severe COVID-19, their clinical progression was different, reinforcing the role of both immune response and genetics in the COVID-19 presentation and course. Besides, post-COVID syndrome was observed in one of them, corroborating an association between the duration of hospitalization and the occurrence of long-COVID symptoms.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionHuman Genome and Stem Cell Research Center University of São Paulo-
Descrição: dc.descriptionDepartment of Genetics and Evolutionary Biology Biosciences Institute University of São Paulo-
Descrição: dc.descriptionMolecular Genetics and Bioinformatics Laboratory Experimental Research Unit (Unipex) School of Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartamento de Clínica Médica Disciplina de Alergia e Imunologia Clínica Faculdade de Medicina da Universidade de São Paulo-
Descrição: dc.descriptionLaboratório de Imunologia Instituto do Coração (InCor) LIM 19 Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP)-
Descrição: dc.descriptionInstituto de Investigação em Imunologia—Instituto Nacional de Ciências e Tecnologia-iii-INCT-
Descrição: dc.descriptionMolecular Genetics and Bioinformatics Laboratory Experimental Research Unit (Unipex) School of Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2013/08028-1-
Descrição: dc.descriptionFAPESP: 2014/50890-5-
Descrição: dc.descriptionFAPESP: 2014/50931-3-
Descrição: dc.descriptionFAPESP: 2020/09702-1-
Descrição: dc.descriptionCNPq: 404134/2020-3-
Descrição: dc.descriptionCNPq: 465355/2014-5-
Descrição: dc.descriptionCNPq: 465434/2014-2-
Descrição: dc.descriptionCAPES: Finance Code 001-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Medicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectgenetic variants-
Palavras-chave: dc.subjectimmunity-
Palavras-chave: dc.subjectmonozygotic twins-
Palavras-chave: dc.subjectSARS-CoV-2-
Título: dc.titleFollow-up of young adult monozygotic twins after simultaneous critical coronavirus disease 2019: A case report-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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