Biomaterial engineering surface to control polymicrobial dental implant-related infections: focusing on disease modulating factors and coatings development

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversity of Pittsburgh-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorGuarulhos University-
Autor(es): dc.contributorDental Science School (Faculdade de Ciências Odontológicas - FCO)-
Autor(es): dc.creatorMalheiros, Samuel S.-
Autor(es): dc.creatorNagay, Bruna E.-
Autor(es): dc.creatorBertolini, Martinna M.-
Autor(es): dc.creatorde Avila, Erica D.-
Autor(es): dc.creatorShibli, Jamil A.-
Autor(es): dc.creatorSouza, João Gabriel S.-
Autor(es): dc.creatorBarão, Valentim A. R.-
Data de aceite: dc.date.accessioned2025-08-21T23:44:00Z-
Data de disponibilização: dc.date.available2025-08-21T23:44:00Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/17434440.2023.2218547-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248937-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248937-
Descrição: dc.descriptionIntroduction: Peri-implantitis is the leading cause of dental implant loss and is initiated by a polymicrobial dysbiotic biofilm formation on the implant surface. The destruction of peri-implant tissue by the host immune response and the low effectiveness of surgical or non-surgical treatments highlight the need for new strategies to prevent, modulate and/or eliminate biofilm formation on the implant surface. Currently, several surface modifications have been proposed using biomolecules, ions, antimicrobial agents, and topography alterations. Areas covered: Initially, this review provides an overview of the etiopathogenesis and host- and material-dependent modulating factors of peri-implant disease. In addition, a critical discussion about the antimicrobial surface modification mechanisms and techniques employed to modify the titanium implant material is provided. Finally, we also considered the future perspectives on the development of antimicrobial surfaces to narrow the bridge between idea and product and favor the clinical application possibility. Expert opinion: Antimicrobial surface modifications have demonstrated effective results; however, there is no consensus about the best modification strategy and in-depth information on the safety and longevity of the antimicrobial effect. Modified surfaces display recurring challenges such as short-term effectiveness, the burst release of drugs, cytotoxicity, and lack of reusability. Stimulus-responsive surfaces seem to be a promising strategy for a controlled and precise antimicrobial effect, and future research should focus on this technology and study it from models that better mimic clinical conditions.-
Descrição: dc.descriptionDepartment of Prosthodontics and Periodontology Piracicaba Dental School University of Campinas (UNICAMP), São Paulo-
Descrição: dc.descriptionDepartment of Periodontics and Preventive Dentistry School of Dental Medicine University of Pittsburgh-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry at Araçatuba São Paulo State University (UNESP), Sao Paulo-
Descrição: dc.descriptionDental Research Division Guarulhos University, São Paulo-
Descrição: dc.descriptionDental Science School (Faculdade de Ciências Odontológicas - FCO), Minas Gerais-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry at Araçatuba São Paulo State University (UNESP), Sao Paulo-
Idioma: dc.languageen-
Relação: dc.relationExpert Review of Medical Devices-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantimicrobial agents-
Palavras-chave: dc.subjectbiofilm-
Palavras-chave: dc.subjectdental implants-
Palavras-chave: dc.subjectperi-implantitis-
Palavras-chave: dc.subjectsurface properties-
Palavras-chave: dc.subjecttitanium-
Título: dc.titleBiomaterial engineering surface to control polymicrobial dental implant-related infections: focusing on disease modulating factors and coatings development-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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