Morphofunctional Improvement of the Facial Nerve and Muscles with Repair Using Heterologous Fibrin Biopolymer and Photobiomodulation

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity Center of Adamantina (UNIFAI)-
Autor(es): dc.contributorUniversity of Marilia (UNIMAR-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Marilia (UNIMAR)-
Autor(es): dc.contributorUniversity of West Paulista (UNOESTE)-
Autor(es): dc.contributorFaculty of the Midwest Paulista (FACOP)-
Autor(es): dc.creatorBueno, Cleuber Rodrigo de Souza-
Autor(es): dc.creatorTonin, Maria Clara Cassola-
Autor(es): dc.creatorBuchaim, Daniela Vieira-
Autor(es): dc.creatorBarraviera, Benedito-
Autor(es): dc.creatorJunior, Rui Seabra Ferreira-
Autor(es): dc.creatorSantos, Paulo Sérgio da Silva-
Autor(es): dc.creatorReis, Carlos Henrique Bertoni-
Autor(es): dc.creatorPastori, Cláudio Maldonado-
Autor(es): dc.creatorPereira, Eliana de Souza Bastos Mazuqueli-
Autor(es): dc.creatorNogueira, Dayane Maria Braz-
Autor(es): dc.creatorCini, Marcelo Augusto-
Autor(es): dc.creatorRosa Junior, Geraldo Marco-
Autor(es): dc.creatorBuchaim, Rogerio Leone-
Data de aceite: dc.date.accessioned2025-08-21T22:36:19Z-
Data de disponibilização: dc.date.available2025-08-21T22:36:19Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ph16050653-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248913-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248913-
Descrição: dc.descriptionPeripheral nerve injuries impair the patient’s functional capacity, including those occurring in the facial nerve, which require effective medical treatment. Thus, we investigated the use of heterologous fibrin biopolymer (HFB) in the repair of the buccal branch of the facial nerve (BBFN) associated with photobiomodulation (PBM), using a low-level laser (LLLT), analyzing the effects on axons, muscles facials, and functional recovery. This experimental study used twenty-one rats randomly divided into three groups of seven animals, using the BBFN bilaterally (the left nerve was used for LLLT): Control group—normal and laser (CGn and CGl); Denervated group—normal and laser (DGn and DGl); Experimental Repair Group—normal and laser (ERGn and ERGl). The photobiomodulation protocol began in the immediate postoperative period and continued for 5 weeks with a weekly application. After 6 weeks of the experiment, the BBFN and the perioral muscles were collected. A significant difference (p < 0.05) was observed in nerve fiber diameter (7.10 ± 0.25 µm and 8.00 ± 0.36 µm, respectively) and axon diameter (3.31 ± 0.19 µm and 4.07 ± 0.27 µm, respectively) between ERGn and ERGl. In the area of muscle fibers, ERGl was similar to GC. In the functional analysis, the ERGn and the ERGI (4.38 ± 0.10) and the ERGI (4.56 ± 0.11) showed parameters of normality. We show that HFB and PBM had positive effects on the morphological and functional stimulation of the buccal branch of the facial nerve, being an alternative and favorable for the regeneration of severe injuries.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru School of Dentistry (FOB/USP) University of São Paulo-
Descrição: dc.descriptionDentistry School University Center of Adamantina (UNIFAI)-
Descrição: dc.descriptionMedical School University Center of Adamantina (UNIFAI)-
Descrição: dc.descriptionPostgraduate Program in Structural and Functional Interactions in Rehabilitation Postgraduate Department University of Marilia (UNIMAR-
Descrição: dc.descriptionCenter for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (Universidade Estadual Paulista UNESP)-
Descrição: dc.descriptionGraduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo State University (UNESP—Universidade Estadual Paulista)-
Descrição: dc.descriptionDepartment of Surgery Stomatology Pathology and Radiology Bauru School of Dentistry University of São Paulo-
Descrição: dc.descriptionUNIMAR Beneficent Hospital (HBU) University of Marilia (UNIMAR)-
Descrição: dc.descriptionDepartment of Prosthodontics and Periodontics Bauru School of Dentistry (FOB/USP) University of São Paulo-
Descrição: dc.descriptionMedical School University of West Paulista (UNOESTE)-
Descrição: dc.descriptionDentistry School Faculty of the Midwest Paulista (FACOP)-
Descrição: dc.descriptionGraduate Program in Anatomy of Domestic and Wild Animals Faculty of Veterinary Medicine and Animal Science University of São Paulo (FMVZ/USP)-
Descrição: dc.descriptionCenter for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (Universidade Estadual Paulista UNESP)-
Descrição: dc.descriptionGraduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo State University (UNESP—Universidade Estadual Paulista)-
Descrição: dc.descriptionFAPESP: 2021/11936-3-
Idioma: dc.languageen-
Relação: dc.relationPharmaceuticals-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbiopolymers-
Palavras-chave: dc.subjectcranial nerve injuries-
Palavras-chave: dc.subjectfacial expression-
Palavras-chave: dc.subjectfacial muscles-
Palavras-chave: dc.subjectfacial nerve-
Palavras-chave: dc.subjectfacial nerve diseases-
Palavras-chave: dc.subjectfibrin tissue adhesive-
Palavras-chave: dc.subjectheterologous-
Palavras-chave: dc.subjectlow-level light therapy-
Palavras-chave: dc.subjecttransplantation-
Título: dc.titleMorphofunctional Improvement of the Facial Nerve and Muscles with Repair Using Heterologous Fibrin Biopolymer and Photobiomodulation-
Tipo de arquivo: dc.typelivro digital-
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