Exercise intolerance in post-coronavirus disease 2019 survivors after hospitalisation

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorSírio-Libanês Teaching and Research Institute-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorLafetá, Mariana L.-
Autor(es): dc.creatorSouza, Vitor C.-
Autor(es): dc.creatorMenezes, Thaís C. F.-
Autor(es): dc.creatorVerrastro, Carlos G. Y.-
Autor(es): dc.creatorMancuso, Frederico J.-
Autor(es): dc.creatorAlbuquerque, André Luis P.-
Autor(es): dc.creatorTanni, Suzana E.-
Autor(es): dc.creatorIzbicki, Meyer-
Autor(es): dc.creatorCarlstron, Júlio P.-
Autor(es): dc.creatorNery, Luiz Eduardo-
Autor(es): dc.creatorOliveira, Rudolf K. F.-
Autor(es): dc.creatorSperandio, Priscila A.-
Autor(es): dc.creatorFerreira, Eloara V. M.-
Data de aceite: dc.date.accessioned2025-08-21T16:28:56Z-
Data de disponibilização: dc.date.available2025-08-21T16:28:56Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1183/23120541.00538-2022-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248910-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248910-
Descrição: dc.descriptionRationale Post-coronavirus disease 2019 (COVID-19) survivors frequently have dyspnoea that can lead to exercise intolerance and lower quality of life. Despite recent advances, the pathophysiological mechanisms of exercise intolerance in the post-COVID-19 patients remain incompletely characterised. The objectives of the present study were to clarify the mechanisms of exercise intolerance in post-COVID-19 survivors after hospitalisation. Methods This prospective study evaluated consecutive patients previously hospitalised due to moderate-tosevere/ critical COVID-19. Within mean±SD 90±10 days of onset of acute COVID-19 symptoms, patients underwent a comprehensive cardiopulmonary assessment, including cardiopulmonary exercise testing with earlobe arterialised capillary blood gas analysis. Measurements and main results 87 patients were evaluated; mean±SD peak oxygen consumption was 19.5±5.0 mL·kg− 1·min− 1, and the tertiles were ≤17.0, 17.1–22.2 and ≥22.3 mL·kg− 1·min− 1. Hospitalisation severity was similar among the three groups; however, at the follow-up visit, patients with peak oxygen consumption ≤17.0 mL·kg− 1·min− 1 reported a greater sensation of dyspnoea, along with indices of impaired pulmonary function, and abnormal ventilatory, gas-exchange and metabolic responses during exercise compared to patients with peak oxygen consumption >17 mL·kg− 1·min− 1. By multivariate logistic regression analysis (receiver operating characteristic curve analysis) adjusted for age, sex and prior pulmonary embolism, a peak dead space fraction of tidal volume ≥29 and a resting forced vital capacity ≤80% predicted were independent predictors of reduced peak oxygen consumption. Conclusions Exercise intolerance in the post-COVID-19 survivors was related to a high dead space fraction of tidal volume at peak exercise and a decreased resting forced vital capacity, suggesting that both pulmonary microcirculation injury and ventilatory impairment could influence aerobic capacity in this patient population.-
Descrição: dc.descriptionPulmonary Function and Clinical Exercise Physiology Unit (SEFICE) Division of Respiratory Diseases Federal University of Sao Paulo (UNIFESP)-
Descrição: dc.descriptionRadiology Division UNIFESP-
Descrição: dc.descriptionDivision of Cardiology UNIFESP-
Descrição: dc.descriptionPulmonary Division Heart Institute (INCOR) Clinical Hospital HCFMUSP Faculty of the Medicine University of Sao Paulo-
Descrição: dc.descriptionSírio-Libanês Teaching and Research Institute-
Descrição: dc.descriptionDivision of Internal Medicine of Botucatu Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDivision of Internal Medicine of Botucatu Medical School São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationERJ Open Research-
???dc.source???: dc.sourceScopus-
Título: dc.titleExercise intolerance in post-coronavirus disease 2019 survivors after hospitalisation-
Tipo de arquivo: dc.typelivro digital-
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