Effects of Creatine Supplementation on the Myostatin Pathway and Myosin Heavy Chain Isoforms in Different Skeletal Muscles of Resistance-Trained Rats

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Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorde Carvalho, Marianna Rabelo-
Autor(es): dc.creatorDuarte, Ellen Fernandes-
Autor(es): dc.creatorMendonça, Maria Lua Marques-
Autor(es): dc.creatorde Morais, Camila Souza-
Autor(es): dc.creatorOta, Gabriel Elias-
Autor(es): dc.creatorGaspar-Junior, Jair José-
Autor(es): dc.creatorde Oliveira Filiú, Wander Fernando-
Autor(es): dc.creatorDamatto, Felipe Cesar-
Autor(es): dc.creatorOkoshi, Marina Politi-
Autor(es): dc.creatorOkoshi, Katashi-
Autor(es): dc.creatorOliveira, Rodrigo Juliano-
Autor(es): dc.creatorMartinez, Paula Felippe-
Autor(es): dc.creatorde Oliveira-Junior, Silvio Assis-
Data de aceite: dc.date.accessioned2025-08-21T20:44:54Z-
Data de disponibilização: dc.date.available2025-08-21T20:44:54Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/nu15092224-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248808-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248808-
Descrição: dc.descriptionCreatine has been used to maximize resistance training effects on skeletal muscles, including muscle hypertrophy and fiber type changes. This study aimed to evaluate the impact of creatine supplementation on the myostatin pathway and myosin heavy chain (MyHC) isoforms in the slow- and fast-twitch muscles of resistance-trained rats. Twenty-eight male Wistar rats were divided into four groups: a sedentary control (Cc), sedentary creatine supplementation (Cr), resistance training (Tc), and resistance training combined with creatine supplementation (Tcr). Cc and Tc received standard commercial chow; Cr and Tcr received a 2% creatine-supplemented diet. Tc and Tcr performed a resistance training protocol on a ladder for 12 weeks. Morphology, MyHC isoforms, myostatin, follistatin, and ActRIIB protein expressions were analyzed in soleus and white gastrocnemius portion samples. The results were analyzed using two-way ANOVA and Tukey’s test. Tc and Tcr exhibited higher performance than their control counterparts. Resistance training increased the ratio between muscle and body weight, the cross-sectional area, as well as the interstitial collagen fraction. Resistance training alone increased MyHC IIx and follistatin while reducing myostatin (p < 0.001) and ActRIIB (p = 0.040) expressions in the gastrocnemius. Resistance training induced skeletal muscle hypertrophy and interstitial remodeling, which are more evident in the gastrocnemius muscle. The effects were not impacted by creatine supplementation.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionGraduate Program in Health and Development in the Midwestern Region Federal University of Mato Grosso do Sul (UFMS), MS-
Descrição: dc.descriptionFaculty of Pharmaceutical Sciences Food and Nutrition Federal University of Mato Grosso do Sul (UFMS), MS-
Descrição: dc.descriptionInternal Medicine Department Botucatu Medical School Sao Paulo State University (UNESP), SP-
Descrição: dc.descriptionGraduate Program in Movement Sciences Federal University of Mato Grosso do Sul (UFMS), MS-
Descrição: dc.descriptionInternal Medicine Department Botucatu Medical School Sao Paulo State University (UNESP), SP-
Descrição: dc.descriptionCNPq: CNPq proc. 420495/2016-9-
Idioma: dc.languageen-
Relação: dc.relationNutrients-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcreatine-
Palavras-chave: dc.subjectmuscle anabolism-
Palavras-chave: dc.subjectmuscle fibers-
Palavras-chave: dc.subjectmyostatin-
Palavras-chave: dc.subjectstrength training-
Título: dc.titleEffects of Creatine Supplementation on the Myostatin Pathway and Myosin Heavy Chain Isoforms in Different Skeletal Muscles of Resistance-Trained Rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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