Integration of nutrigenomics, melatonin, serotonin and inflammatory cytokines in the pathophysiology of pregnancy-specific urinary incontinence in women with gestational diabetes mellitus

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Mato Grosso (UFMT)-
Autor(es): dc.contributorPontificia Universidad Católica de Chile-
Autor(es): dc.contributorUniversidad de Sevilla-
Autor(es): dc.contributorUniversity of Queensland-
Autor(es): dc.contributorUniversity of Groningen-
Autor(es): dc.contributorSchool of Medicine and Health Sciences-
Autor(es): dc.creatorFrança, Danielle Cristina Honorio-
Autor(es): dc.creatorFrança, Eduardo Luzía-
Autor(es): dc.creatorSobrevia, Luis-
Autor(es): dc.creatorBarbosa, Angélica Mércia Pascon-
Autor(es): dc.creatorHonorio-França, Adenilda Cristina-
Autor(es): dc.creatorRudge, Marilza Vieira Cunha-
Data de aceite: dc.date.accessioned2025-08-21T16:43:15Z-
Data de disponibilização: dc.date.available2025-08-21T16:43:15Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bbadis.2023.166737-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248800-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248800-
Descrição: dc.descriptionGestational diabetes mellitus is an important public health problem and has been associated with the development of pregnancy-specific urinary incontinence. The interaction is related to hyperglycemia, and inflammatory and hormonal patterns, which favor functional alterations in different organs and systems. Several genes associated with human diseases have been identified and partially characterized. Most of these genes are known to cause monogenic diseases. However, about 3 % of diseases do not fit the monogenic theory due to the complex interactions between multiple genes and environmental factors, as in chronic metabolic diseases such as diabetes. The nutritional, immunological, and hormonal patterns associated with changes in maternal metabolism may influence and contribute to greater susceptibility to urinary tract disorders. However, early systematic reviews have not yielded consistent findings for these associations. This literature review summarizes important new findings from integrating nutrigenomics, hormones, and cytokines in women with Gestational diabetes mellitus and pregnancy-specific urinary incontinence. Changes in maternal metabolism due to hyperglycemia can generate an inflammatory environment with increased inflammatory cytokines. This environment modulated by inflammation can alter tryptophan uptake through food and thus influence the production of serotonin and melatonin. As these hormones seem to have protective effects against smooth muscle dysfunction and to restore the impaired contractility of the detrusor muscle, it is assumed that these changes may favor the onset of urinary incontinence specific to pregnancy.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionPontificia Universidad Católica de Chile-
Descrição: dc.descriptionUniversidade Estadual Paulista-
Descrição: dc.descriptionFondo Nacional de Desarrollo Científico y Tecnológico-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Medical School (FMB) São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Biological and Health Science Federal University of Mato Grosso (UFMT)-
Descrição: dc.descriptionCellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaecology School of Medicine Faculty of Medicine Pontificia Universidad Católica de Chile-
Descrição: dc.descriptionDepartment of Physiology Faculty of Pharmacy Universidad de Sevilla-
Descrição: dc.descriptionFaculty of Medicine and Biomedical Sciences University of Queensland-
Descrição: dc.descriptionDepartment of Pathology and Medical Biology University of Groningen-
Descrição: dc.descriptionTecnologico de Monterrey Eutra The Institute for Obesity Research (IOR) School of Medicine and Health Sciences-
Descrição: dc.descriptionDepartment of Physiotherapy and Occupational Therapy School of Philosophy and Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu Medical School (FMB) São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Physiotherapy and Occupational Therapy School of Philosophy and Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionFondo Nacional de Desarrollo Científico y Tecnológico: 1190316-
Descrição: dc.descriptionFAPESP: 2016/01743–5-
Descrição: dc.descriptionCNPq: 305116/2018-5-
Idioma: dc.languageen-
Relação: dc.relationBiochimica et Biophysica Acta - Molecular Basis of Disease-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEpigenetic-
Palavras-chave: dc.subjectHormones-
Palavras-chave: dc.subjectHyperglycemia-
Palavras-chave: dc.subjectImmunomodulation-
Palavras-chave: dc.subjectInvoluntary loss of urine-
Título: dc.titleIntegration of nutrigenomics, melatonin, serotonin and inflammatory cytokines in the pathophysiology of pregnancy-specific urinary incontinence in women with gestational diabetes mellitus-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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