Intestinal Microbiota and miRNA in IBD: A Narrative Review about Discoveries and Perspectives for the Future

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorOliveira, Ellen Cristina Souza de-
Autor(es): dc.creatorQuaglio, Ana Elisa Valencise-
Autor(es): dc.creatorMagro, Daniéla Oliveira-
Autor(es): dc.creatorDi Stasi, Luiz Claudio-
Autor(es): dc.creatorSassaki, Ligia Yukie-
Data de aceite: dc.date.accessioned2025-08-21T20:55:30Z-
Data de disponibilização: dc.date.available2025-08-21T20:55:30Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms24087176-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248771-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248771-
Descrição: dc.descriptionInflammatory bowel disease (IBD) includes Crohn’s disease (CD) and ulcerative colitis (UC) and comprises a chronic gastrointestinal tract disorder characterized by hyperactive and dysregulated immune responses to environmental factors, including gut microbiota and dietary components. An imbalance of the intestinal microbiota may contribute to the development and/or worsening of the inflammatory process. MicroRNAs (miRNAs) have been associated with various physiological processes, such as cell development and proliferation, apoptosis, and cancer. In addition, they play an important role in inflammatory processes, acting in the regulation of pro- and anti-inflammatory pathways. Differences in the profiles of miRNAs may represent a useful tool in the diagnosis of UC and CD and as a prognostic marker in both diseases. The relationship between miRNAs and the intestinal microbiota is not completely elucidated, but recently this topic has gained prominence and has become the target of several studies that demonstrate the role of miRNAs in the modulation of the intestinal microbiota and induction of dysbiosis; the microbiota, in turn, can regulate the expression of miRNAs and, consequently, alter the intestinal homeostasis. Therefore, this review aims to describe the interaction between the intestinal microbiota and miRNAs in IBD, recent discoveries, and perspectives for the future.-
Descrição: dc.descriptionDepartment of Internal Medicine Medical School Sao Paulo State University (UNESP), Campus Botucatu-
Descrição: dc.descriptionLaboratory of Phytomedicines Pharmacology and Biotechnology (PhytoPharmaTec) Department of Biophysics and Pharmacology Institute of Biosciences Sao Paulo State University (UNESP), Campus Botucatu-
Descrição: dc.descriptionDepartment of Surgery Faculty of Medical Sciences State University of Campinas (UNICAMP)-
Descrição: dc.descriptionDepartment of Internal Medicine Medical School Sao Paulo State University (UNESP), Campus Botucatu-
Descrição: dc.descriptionLaboratory of Phytomedicines Pharmacology and Biotechnology (PhytoPharmaTec) Department of Biophysics and Pharmacology Institute of Biosciences Sao Paulo State University (UNESP), Campus Botucatu-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCrohn’s disease-
Palavras-chave: dc.subjectdysbiosis-
Palavras-chave: dc.subjectinflammatory bowel-
Palavras-chave: dc.subjectintestinal microbiota-
Palavras-chave: dc.subjectmicroRNA-
Palavras-chave: dc.subjectulcerative colitis-
Título: dc.titleIntestinal Microbiota and miRNA in IBD: A Narrative Review about Discoveries and Perspectives for the Future-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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