Sequence-Based Platforms for Discovering Biomarkers in Liquid Biopsy of Non-Small-Cell Lung Cancer

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorBritish Columbia Cancer Research Institute-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorIWK Health Centre-
Autor(es): dc.contributorDalhousie University-
Autor(es): dc.contributorBeatrice Hunter Cancer Research Institute-
Autor(es): dc.contributorBritish Columbia Children’s Hospital Research Institute-
Autor(es): dc.creatorBrockley, Liam J.-
Autor(es): dc.creatorSouza, Vanessa G. P.-
Autor(es): dc.creatorForder, Aisling-
Autor(es): dc.creatorPewarchuk, Michelle E.-
Autor(es): dc.creatorErkan, Melis-
Autor(es): dc.creatorTelkar, Nikita-
Autor(es): dc.creatorBenard, Katya-
Autor(es): dc.creatorTrejo, Jessica-
Autor(es): dc.creatorStewart, Matt D.-
Autor(es): dc.creatorStewart, Greg L.-
Autor(es): dc.creatorReis, Patricia P.-
Autor(es): dc.creatorLam, Wan L.-
Autor(es): dc.creatorMartinez, Victor D.-
Data de aceite: dc.date.accessioned2025-08-21T15:11:57Z-
Data de disponibilização: dc.date.available2025-08-21T15:11:57Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/cancers15082275-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248754-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248754-
Descrição: dc.descriptionLung cancer detection and monitoring are hampered by a lack of sensitive biomarkers, which results in diagnosis at late stages and difficulty in tracking response to treatment. Recent developments have established liquid biopsies as promising non-invasive methods for detecting biomarkers in lung cancer patients. With concurrent advances in high-throughput sequencing technologies and bioinformatics tools, new approaches for biomarker discovery have emerged. In this article, we survey established and emerging biomarker discovery methods using nucleic acid materials derived from bodily fluids in the context of lung cancer. We introduce nucleic acid biomarkers extracted from liquid biopsies and outline biological sources and methods of isolation. We discuss next-generation sequencing (NGS) platforms commonly used to identify novel biomarkers and describe how these have been applied to liquid biopsy. We highlight emerging biomarker discovery methods, including applications of long-read sequencing, fragmentomics, whole-genome amplification methods for single-cell analysis, and whole-genome methylation assays. Finally, we discuss advanced bioinformatics tools, describing methods for processing NGS data, as well as recently developed software tailored for liquid biopsy biomarker detection, which holds promise for early diagnosis of lung cancer.-
Descrição: dc.descriptionUniversity of British Columbia-
Descrição: dc.descriptionBC Cancer Foundation-
Descrição: dc.descriptionCanadian Institutes of Health Research-
Descrição: dc.descriptionBritish Columbia Cancer Research Institute-
Descrição: dc.descriptionMolecular Oncology Laboratory Experimental Research Unit School of Medicine São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Pathology and Laboratory Medicine IWK Health Centre-
Descrição: dc.descriptionDepartment of Pathology Faculty of Medicine Dalhousie University-
Descrição: dc.descriptionBeatrice Hunter Cancer Research Institute-
Descrição: dc.descriptionBritish Columbia Children’s Hospital Research Institute-
Descrição: dc.descriptionDepartment of Surgery and Orthopedics Faculty of Medicine São Paulo State University (UNESP), SP-
Descrição: dc.descriptionMolecular Oncology Laboratory Experimental Research Unit School of Medicine São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Surgery and Orthopedics Faculty of Medicine São Paulo State University (UNESP), SP-
Descrição: dc.descriptionCanadian Institutes of Health Research: FRN-143345-
Descrição: dc.descriptionCanadian Institutes of Health Research: FRN-183775-
Idioma: dc.languageen-
Relação: dc.relationCancers-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbioinformatics-
Palavras-chave: dc.subjectCTCs-
Palavras-chave: dc.subjectctDNA-
Palavras-chave: dc.subjecthigh throughput-
Palavras-chave: dc.subjectliquid biopsy-
Palavras-chave: dc.subjectlung cancer-
Palavras-chave: dc.subjectNGS-
Título: dc.titleSequence-Based Platforms for Discovering Biomarkers in Liquid Biopsy of Non-Small-Cell Lung Cancer-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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