Risk factors for mortality in 1528 Brazilian childhood-onset systemic lupus erythematosus patients

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Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorHospital da Crianca de Brasilia Jose Alencar-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorHospital Geral de Fortaleza-
Autor(es): dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)-
Autor(es): dc.contributorErnesto University Hospital-
Autor(es): dc.contributorIrmandade da Santa Casa de Misericordia de Sao Paulo-
Autor(es): dc.contributorJoao Pessoa-
Autor(es): dc.contributorFederal University of Para-
Autor(es): dc.contributorHospital Darcy Vargas-
Autor(es): dc.contributorUniversidade Federal da Bahia (UFBA)-
Autor(es): dc.contributorHospital Evangelico de Curitiba-
Autor(es): dc.contributorHospital Criança Conceição-
Autor(es): dc.contributorUniversidade Federal de Pernambuco (UFPE)-
Autor(es): dc.contributorFederal University of Mato Grosso do Sul-
Autor(es): dc.contributorUniversity of Brasilia-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.creatorSakamoto, Ana P-
Autor(es): dc.creatorSilva, Clovis A-
Autor(es): dc.creatorPita, Ana C-
Autor(es): dc.creatorTrindade, Vitor C-
Autor(es): dc.creatorIslabao, Aline G-
Autor(es): dc.creatorFiorot, Fernanda J-
Autor(es): dc.creatorLopes, Sandra RM-
Autor(es): dc.creatorPereira, Rosa MR-
Autor(es): dc.creatorSaad-Magalhaes, Claudia-
Autor(es): dc.creatorRusso, Gleice CS-
Autor(es): dc.creatorLen, Claudio A-
Autor(es): dc.creatorPrado, Rogerio do-
Autor(es): dc.creatorCampos, Lucia MA-
Autor(es): dc.creatorAikawa, Nadia E-
Autor(es): dc.creatorAppenzeller, Simone-
Autor(es): dc.creatorFerriani, Virginia PL-
Autor(es): dc.creatorSilva, Marco F-
Autor(es): dc.creatorFelix, Marta-
Autor(es): dc.creatorFonseca, Adriana R-
Autor(es): dc.creatorAssad, Ana PL-
Autor(es): dc.creatorSztajnbok, Flavio R-
Autor(es): dc.creatorSantos, Maria C-
Autor(es): dc.creatorBica, Blanca E-
Autor(es): dc.creatorSena, Evaldo G-
Autor(es): dc.creatorMoraes, Ana J-
Autor(es): dc.creatorFraga, Melissa M-
Autor(es): dc.creatorRobazzi, Teresa C-
Autor(es): dc.creatorSpelling, Paulo F-
Autor(es): dc.creatorScheibel, Iloite M-
Autor(es): dc.creatorCavalcanti, Andre S-
Autor(es): dc.creatorMatos, Erica N-
Autor(es): dc.creatorGuimaraes, Luciano J-
Autor(es): dc.creatorSantos, Flavia P-
Autor(es): dc.creatorMota, Licia MH-
Autor(es): dc.creatorBonfa, Eloisa-
Autor(es): dc.creatorTerreri, Maria T-
Data de aceite: dc.date.accessioned2025-08-21T19:24:58Z-
Data de disponibilização: dc.date.available2025-08-21T19:24:58Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1177/09612033231170515-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248730-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248730-
Descrição: dc.descriptionObjectives: To identify associations between mortality in cSLE patients and their characteristics: clinical and laboratory features, disease activity and damage scores, and treatment; to evaluate risk factors associated with mortality in cSLE; and to determine the most frequent causes of death in this group of patients. Methods: We performed a multicenter retrospective cohort using data from 1,528 cSLE patients followed in 27 pediatric rheumatology tertiary centers in Brazil. Patients’ medical records were reviewed according to a standardized protocol, in which information regarding demographic and clinical features, disease activity and damage scores, and treatment were collected and compared between deceased cSLE patients and survivors. Univariate and multivariate analyses by Cox regression model were used to calculate risk factors for mortality, whereas survival rates were analyzed by Kaplan–Meier plots. Results: A total of 63/1,528 (4.1%) patients deceased, 53/63 were female (84.1%), median age at death was 11.9 (9.4–13.1) years and median time interval between cSLE diagnosis and death was 3.2 (0.5–5.3) years. Sepsis was the main cause of death in 27/63 (42.8%) patients, followed by opportunistic infections in 7/63 (11.1%), and alveolar hemorrhage in 6/63 (9.5%) patients. The regression models resulted in neuropsychiatric lupus (NP-SLE) (HR = 2.56, 95% CI = 1.48–4.42) and chronic kidney disease (CKD) (HR = 4.33, 95% CI = 2.33–4.72), as risk factors significantly associated with mortality. Overall patient survival after cSLE diagnosis at 5, 10, and 15 years were 97%, 95.4%, and 93.8%, respectively. Conclusions: This study confirmed that the recent mortality rate in cSLE in Brazil is low, but still of concern. NP-SLE and CKD were the main risk factors for mortality, indicating that the magnitude of these manifestations was significantly high.-
Descrição: dc.descriptionPediatric Rheumatology Unit Universidade Federal de Sao Paulo, SP-
Descrição: dc.descriptionPediatric Rheumatology Unit Faculdade de Medicina Universidade de Sao Paulo-
Descrição: dc.descriptionPediatric Rheumatology Unit Hospital da Crianca de Brasilia Jose Alencar, DF-
Descrição: dc.descriptionDivision of Rheumatology Hospital das Clinicas HCFMUSP Universidade de Sao Paulo, SP-
Descrição: dc.descriptionPediatric Rheumatology Division Sao Paulo State University (UNESP) Faculdade de Medicina de Botucatu, SP-
Descrição: dc.descriptionDepartment of Orthopedics Rheumatology and Traumatology – School of Medical Science University of Campinas (UNICAMP), SP-
Descrição: dc.descriptionPediatric Rheumatology Unit Preto Medical School University of Sao Paulo, SP-
Descrição: dc.descriptionPediatric Rheumatology Unit Hospital Geral de Fortaleza, CE-
Descrição: dc.descriptionPediatric Rheumatology Unit Universidade Federal do Rio de Janeiro (UFRJ), RJ-
Descrição: dc.descriptionPediatric Rheumatology Unit Ernesto University Hospital, RJ-
Descrição: dc.descriptionPediatric Rheumatology Unit Irmandade da Santa Casa de Misericordia de Sao Paulo, SP-
Descrição: dc.descriptionRheumatology Division - Universidade Federal do Rio de Janeiro Rio de Janeiro, RJ-
Descrição: dc.descriptionPediatric Rheumatology Unit Lauro Vanderley University Hospital Joao Pessoa, PB-
Descrição: dc.descriptionPediatric Rheumatology Unit Federal University of Para, PA-
Descrição: dc.descriptionPediatric Rheumatology Unit Hospital Darcy Vargas, SP-
Descrição: dc.descriptionPediatric Rheumatology Unit Federal University of Bahia, Salvador, BA-
Descrição: dc.descriptionPediatric Rheumatology Unit Hospital Evangelico de Curitiba, PR-
Descrição: dc.descriptionPediatric Rheumatology Unit Hospital Criança Conceicao, Porto Alegre, RS-
Descrição: dc.descriptionPediatric Rheumatology Unit Federal University of Pernambuco, PE-
Descrição: dc.descriptionPediatric Rheumatology Unit Federal University of Mato Grosso do Sul, Campo Grande, MS-
Descrição: dc.descriptionPediatric Rheumatology Unit University of Brasilia, DF-
Descrição: dc.descriptionPediatric Rheumatology Unit Federal University of Minas Gerais, Belo Horizonte, MG-
Descrição: dc.descriptionRheumatology Unit University of Brasilia, DF-
Descrição: dc.descriptionPediatric Rheumatology Division Sao Paulo State University (UNESP) Faculdade de Medicina de Botucatu, SP-
Formato: dc.format781-790-
Idioma: dc.languageen-
Relação: dc.relationLupus-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectChildhood-
Palavras-chave: dc.subjectchildhood-onset systemic lupus erythematosus-
Palavras-chave: dc.subjectlupus nephritis-
Palavras-chave: dc.subjectmortality-
Palavras-chave: dc.subjectsepsis-
Título: dc.titleRisk factors for mortality in 1528 Brazilian childhood-onset systemic lupus erythematosus patients-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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