Photobiomodulation Reduces the Cytokine Storm Syndrome Associated with COVID-19 in the Zebrafish Model

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorSão Leopoldo Mandic College-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorINCTBio-
Autor(es): dc.contributorOswaldo Cruz Foundation (Fiocruz)-
Autor(es): dc.contributorUniversidade de Passo Fundo-
Autor(es): dc.contributorFederal University Minas Gerais-
Autor(es): dc.contributorNord University-
Autor(es): dc.contributorFederal University of Jatai-
Autor(es): dc.contributorUniversidade Federal de Pernambuco (UFPE)-
Autor(es): dc.contributorFederal University of Alfenas-
Autor(es): dc.contributorFIOCRUZ Paraná-
Autor(es): dc.contributorLaboratory of Development and Innovation Butantan Institute-
Autor(es): dc.contributorGoiano Federal Institute-
Autor(es): dc.creatorRosa, Ivana F.-
Autor(es): dc.creatorPeçanha, Ana P. B.-
Autor(es): dc.creatorCarvalho, Tábata R. B.-
Autor(es): dc.creatorAlexandre, Leonardo S.-
Autor(es): dc.creatorFerreira, Vinícius G.-
Autor(es): dc.creatorDoretto, Lucas B.-
Autor(es): dc.creatorSouza, Beatriz M.-
Autor(es): dc.creatorNakajima, Rafael T.-
Autor(es): dc.creatorda Silva, Patrick-
Autor(es): dc.creatorBarbosa, Ana P.-
Autor(es): dc.creatorGomes-de-Pontes, Leticia-
Autor(es): dc.creatorBomfim, Camila G.-
Autor(es): dc.creatorMachado-Santelli, Glaucia M.-
Autor(es): dc.creatorCondino-Neto, Antonio-
Autor(es): dc.creatorGuzzo, Cristiane R.-
Autor(es): dc.creatorPeron, Jean P. S.-
Autor(es): dc.creatorAndrade-Silva, Magaiver-
Autor(es): dc.creatorCâmara, Niels O. S.-
Autor(es): dc.creatorGarnique, Anali M. B.-
Autor(es): dc.creatorMedeiros, Renata J.-
Autor(es): dc.creatorFerraris, Fausto K.-
Autor(es): dc.creatorBarcellos, Leonardo J. G.-
Autor(es): dc.creatorCorreia-Junior, Jose D.-
Autor(es): dc.creatorGalindo-Villegas, Jorge-
Autor(es): dc.creatorMachado, Mônica F. R.-
Autor(es): dc.creatorCastoldi, Angela-
Autor(es): dc.creatorOliveira, Susana L.-
Autor(es): dc.creatorCosta, Camila C.-
Autor(es): dc.creatorBelo, Marco A. A.-
Autor(es): dc.creatorGaldino, Giovane-
Autor(es): dc.creatorSgro, Germán G.-
Autor(es): dc.creatorBueno, Natalia F.-
Autor(es): dc.creatorEto, Silas F.-
Autor(es): dc.creatorVeras, Flávio P.-
Autor(es): dc.creatorFernandes, Bianca H. V.-
Autor(es): dc.creatorSanches, Paulo R. S.-
Autor(es): dc.creatorCilli, Eduardo M.-
Autor(es): dc.creatorMalafaia, Guilherme-
Autor(es): dc.creatorNóbrega, Rafael H.-
Autor(es): dc.creatorGarcez, Aguinaldo S.-
Autor(es): dc.creatorCarrilho, Emanuel-
Autor(es): dc.creatorCharlie-Silva, Ives-
Data de aceite: dc.date.accessioned2025-08-21T22:58:22Z-
Data de disponibilização: dc.date.available2025-08-21T22:58:22Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms24076104-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248713-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248713-
Descrição: dc.descriptionAlthough the exact mechanism of the pathogenesis of coronavirus SARS-CoV-2 (COVID-19) is not fully understood, oxidative stress and the release of pro-inflammatory cytokines have been highlighted as playing a vital role in the pathogenesis of the disease. In this sense, alternative treatments are needed to reduce the level of inflammation caused by COVID-19. Therefore, this study aimed to investigate the potential effect of red photobiomodulation (PBM) as an attractive therapy to downregulate the cytokine storm caused by COVID-19 in a zebrafish model. RT-qPCR analyses and protein–protein interaction prediction among SARS-CoV-2 and Danio rerio proteins showed that recombinant Spike protein (rSpike) was responsible for generating systemic inflammatory processes with significantly increased levels of pro-inflammatory (il1b, il6, tnfa, and nfkbiab), oxidative stress (romo1) and energy metabolism (slc2a1a and coa1) mRNA markers, with a pattern similar to those observed in COVID-19 cases in humans. On the other hand, PBM treatment was able to decrease the mRNA levels of these pro-inflammatory and oxidative stress markers compared with rSpike in various tissues, promoting an anti-inflammatory response. Conversely, PBM promotes cellular and tissue repair of injured tissues and significantly increases the survival rate of rSpike-inoculated individuals. Additionally, metabolomics analysis showed that the most-impacted metabolic pathways between PBM and the rSpike treated groups were related to steroid metabolism, immune system, and lipid metabolism. Together, our findings suggest that the inflammatory process is an incisive feature of COVID-19 and red PBM can be used as a novel therapeutic agent for COVID-19 by regulating the inflammatory response. Nevertheless, the need for more clinical trials remains, and there is a significant gap to overcome before clinical trials can commence.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Orthodontics São Leopoldo Mandic College-
Descrição: dc.descriptionInstituto de Química de São Carlos Universidade de São Paulo-
Descrição: dc.descriptionThe National Institute of Science and Technology in Bioanalyses INCTBio-
Descrição: dc.descriptionInstitute of Biomedical Sciences University of São Paulo (USP)-
Descrição: dc.descriptionOswaldo Cruz Foundation (Fiocruz)-
Descrição: dc.descriptionLaboratório de Fisiologia de Peixes Programa de Pós-Graduação em Bioexperimentação Escola de Ciências Agrárias Inovação e Negócios Universidade de Passo Fundo-
Descrição: dc.descriptionInstitute of Biomedical Sciences Federal University Minas Gerais-
Descrição: dc.descriptionDepartment of Genomics Faculty of Biosciences and Aquaculture Nord University-
Descrição: dc.descriptionBiological Sciences Special Academic Unit Federal University of Jatai-
Descrição: dc.descriptionKeizo Asami Institute Federal University of Pernambuco-
Descrição: dc.descriptionSchool of Agricultural and Veterinary Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Motricity Sciences Department of Physical Therapy Federal University of Alfenas-
Descrição: dc.descriptionDepartamento de Ciências Biomoleculares Faculdade de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo-
Descrição: dc.descriptionIntegrated Structural Biology Platform Carlos Chagas Institute FIOCRUZ Paraná-
Descrição: dc.descriptionCenter of Innovation and Development Laboratory of Development and Innovation Butantan Institute-
Descrição: dc.descriptionFaculty of Medicine University of São Paulo (USP)-
Descrição: dc.descriptionLaboratory of Genetic and Sanitary Control Technical Board of Support for Teaching and Research Faculty of Medicine University of Sao Paulo-
Descrição: dc.descriptionDepartment of Biochemistry and Organic Chemistry Institute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratory of Toxicology Applied to the Environment Goiano Federal Institute, Urutaí Campus-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Agricultural and Veterinary Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biochemistry and Organic Chemistry Institute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionCAPES: 0459/20-
Descrição: dc.descriptionCAPES: 110-
Descrição: dc.descriptionCAPES: 465389/2014-7-
Descrição: dc.descriptionCAPES: 88887.504531/2020-00-
Descrição: dc.descriptionCAPES: Project CG 19-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectcytokine storms-
Palavras-chave: dc.subjectoxidative stress-
Palavras-chave: dc.subjectphotobiomodulation-
Palavras-chave: dc.subjectrSpike-
Palavras-chave: dc.subjectzebrafish-
Título: dc.titlePhotobiomodulation Reduces the Cytokine Storm Syndrome Associated with COVID-19 in the Zebrafish Model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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