Evidence Linking PPARG Genetic Variants with Periodontitis and Type 2 Diabetes Mellitus in a Brazilian Population

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Autor(es): dc.contributorUniversity Center—UNIFAE-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUnion of the Colleges of the Great Lakes—UNILAGO-
Autor(es): dc.contributorUniversity of North Carolina at Chapel Hill—UNC-
Autor(es): dc.creatorCirelli, Thamiris-
Autor(es): dc.creatorNicchio, Ingra G.-
Autor(es): dc.creatorBussaneli, Diego G.-
Autor(es): dc.creatorSilva, Bárbara R.-
Autor(es): dc.creatorNepomuceno, Rafael-
Autor(es): dc.creatorOrrico, Silvana R. P.-
Autor(es): dc.creatorCirelli, Joni A.-
Autor(es): dc.creatorTheodoro, Letícia H.-
Autor(es): dc.creatorBarros, Silvana P.-
Autor(es): dc.creatorScarel-Caminaga, Raquel M.-
Data de aceite: dc.date.accessioned2025-08-21T21:12:18Z-
Data de disponibilização: dc.date.available2025-08-21T21:12:18Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms24076760-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248709-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248709-
Descrição: dc.descriptionThe peroxisome proliferator-activated receptor gamma (PPARG) gene encodes a transcription factor involved in the regulation of complex metabolic and inflammatory diseases. We investigated whether single nucleotide polymorphisms (SNPs) and haplotypes of the PPARG gene could contribute with susceptibility to develop periodontitis alone or together with type 2 diabetes mellitus (T2DM). Moreover, we evaluated the gene–phenotype association by assessing the subjects’ biochemical and periodontal parameters, and the expression of PPARG and other immune response–related genes. We examined 345 subjects with a healthy periodontium and without T2DM, 349 subjects with moderate or severe periodontitis but without T2DM, and 202 subjects with moderate or severe periodontitis and T2DM. PPARG SNPs rs12495364, rs1801282, rs1373640, and rs1151999 were investigated. Multiple logistic regressions adjusted for age, sex, and smoking status showed that individuals carrying rs1151999-GG had a 64% lower chance of developing periodontitis together with T2DM. The CCGT haplotype increased the risk of developing periodontitis together with T2DM. The rs1151999-GG and rs12495364-TC were associated with reduced risk of obesity, periodontitis, elevated triglycerides, and elevated glycated hemoglobin, but there was no association with gene expression. Polymorphisms of the PPARG gene were associated with developing periodontitis together with T2DM, and with obesity, lipid, glycemic, and periodontal characteristics.-
Descrição: dc.descriptionDepartment of Dentistry School of Dentistry University Center—UNIFAE, SP-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry at Araraquara São Paulo State University—UNESP, SP-
Descrição: dc.descriptionDepartment of Morphology Genetics Orthodontics and Pediatric Dentistry School of Dentistry at Araraquara São Paulo State University—UNESP, SP-
Descrição: dc.descriptionAdvanced Research Center in Medicine Union of the Colleges of the Great Lakes—UNILAGO, SP-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry at Araçatuba São Paulo State University—UNESP, SP-
Descrição: dc.descriptionDepartment of Periodontology School of Dentistry University of North Carolina at Chapel Hill—UNC-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry at Araraquara São Paulo State University—UNESP, SP-
Descrição: dc.descriptionDepartment of Morphology Genetics Orthodontics and Pediatric Dentistry School of Dentistry at Araraquara São Paulo State University—UNESP, SP-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry at Araçatuba São Paulo State University—UNESP, SP-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectdyslipidemias-
Palavras-chave: dc.subjectobesity-
Palavras-chave: dc.subjectperiodontitis-
Palavras-chave: dc.subjectperoxisome proliferator-activated receptors-
Palavras-chave: dc.subjectsingle nucleotide polymorphisms-
Palavras-chave: dc.subjecttype 2 diabetes mellitus-
Título: dc.titleEvidence Linking PPARG Genetic Variants with Periodontitis and Type 2 Diabetes Mellitus in a Brazilian Population-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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