Towards development of treat to target (T2T) in childhood-onset systemic lupus erythematosus: PReS-endorsed overarching principles and points-to-consider from an international task force

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Autor(es): dc.contributorUniversity of Liverpool Faculty of Health and Life Sciences-
Autor(es): dc.contributorAlder Hey Children's Nhs Foundation Trust-
Autor(es): dc.contributorSanjay Gandhi Post Graduate Institute of Medical Sciences-
Autor(es): dc.contributorBirmingham Children's Hospital Nhs Foundation Trust-
Autor(es): dc.contributorDivision of Paediatrics-
Autor(es): dc.contributorThe Children's Hospital of Philadelphia-
Autor(es): dc.contributorUniversity College London-
Autor(es): dc.contributorErasmus Medical Center-
Autor(es): dc.contributorThe Hospital for Sick Children-
Autor(es): dc.contributorUniversity of Toronto-
Autor(es): dc.contributorNational Institute of Arthritis and Musculoskeletal and Skin Diseases Systemic Autoimmunity Branch-
Autor(es): dc.contributorMonash University-
Autor(es): dc.contributorHacettepe University Faculty of Medicine-
Autor(es): dc.contributorIstituto Giannina Gaslini Istituto Pediatrico di Ricovero e Cura A Carattere Scientifico-
Autor(es): dc.contributorUniversità Degli Studi di Genova-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorGreat Ormond Street Hospital for Children-
Autor(es): dc.contributorUniversity of Amsterdam-
Autor(es): dc.contributorAmsterdam University Medical Centres-
Autor(es): dc.contributorUniversity of Cape Town-
Autor(es): dc.creatorSmith, Eve Mary Dorothy-
Autor(es): dc.creatorAggarwal, Amita-
Autor(es): dc.creatorAinsworth, Jenny-
Autor(es): dc.creatorAl-Abadi, Eslam-
Autor(es): dc.creatorAvcin, Tadej-
Autor(es): dc.creatorBortey, Lynette-
Autor(es): dc.creatorBurnham, Jon-
Autor(es): dc.creatorCiurtin, Coziana-
Autor(es): dc.creatorHedrich, Christian M-
Autor(es): dc.creatorKamphuis, Sylvia-
Autor(es): dc.creatorLevy, Deborah M-
Autor(es): dc.creatorLewandowski, Laura B-
Autor(es): dc.creatorMaxwell, Naomi-
Autor(es): dc.creatorMorand, Eric F-
Autor(es): dc.creatorOzen, Seza-
Autor(es): dc.creatorPain, Clare E-
Autor(es): dc.creatorRavelli, Angelo-
Autor(es): dc.creatorSaad Magalhaes, Claudia-
Autor(es): dc.creatorPilkington, Clarissa A-
Autor(es): dc.creatorSchonenberg-Meinema, Dieneke-
Autor(es): dc.creatorScott, Christiaan-
Autor(es): dc.creatorTullus, Kjell-
Autor(es): dc.creatorBeresford, Michael William-
Data de aceite: dc.date.accessioned2025-08-21T22:38:48Z-
Data de disponibilização: dc.date.available2025-08-21T22:38:48Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1136/ard-2022-223328-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248668-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248668-
Descrição: dc.descriptionObjectives Application of 'treat-to-target' (T2T) in childhood-onset systemic lupus erythematosus (cSLE) may improve care and health outcomes. This initiative aimed to harmonise existing evidence and expert opinion regarding T2T for cSLE. Methods An international T2T Task Force was formed of specialists in paediatric rheumatology, paediatric nephrology, adult rheumatology, patient and parent representatives. A steering committee formulated a set of draft overarching principles and points-to-consider, based on evidence from systematic literature review. Two on-line preconsensus meeting Delphi surveys explored healthcare professionals' views on these provisional overarching principles and points-to-consider. A virtual consensus meeting employed a modified nominal group technique to discuss, modify and vote on each overarching principle/point-to-consider. Agreement of >80% of Task Force members was considered consensus. Results The Task Force agreed on four overarching principles and fourteen points-to-consider. It was agreed that both treatment targets and therapeutic strategies should be subject to shared decision making with the patient/caregivers, with full remission the preferred target, and low disease activity acceptable where remission cannot be achieved. Important elements of the points-to-consider included: aiming for prevention of flare and organ damage; glucocorticoid sparing; proactively addressing factors that impact health-related quality of life (fatigue, pain, mental health, educational challenges, medication side effects); and aiming for maintenance of the target over the long-term. An extensive research agenda was also formulated. Conclusions These international, consensus agreed overarching principles and points-to-consider for T2T in cSLE lay the foundation for future T2T approaches in cSLE, endorsed by the Paediatric Rheumatology European Society.-
Descrição: dc.descriptionDepartment of Women's & Children's Health Institute of Life Course and Medical Sciences University of Liverpool Faculty of Health and Life Sciences-
Descrição: dc.descriptionDepartment of Paediatric Rheumatology Alder Hey Children's Nhs Foundation Trust-
Descrição: dc.descriptionDepartment of Clinical Immunology & Rheumatology Sanjay Gandhi Post Graduate Institute of Medical Sciences, Uttar Pradesh-
Descrição: dc.descriptionDepartment of Paediatric Rheumatology Birmingham Children's Hospital Nhs Foundation Trust-
Descrição: dc.descriptionDepartment of Pediatric Rheumatology and Clinical Immunology University Medical Centre Ljubljana Division of Paediatrics-
Descrição: dc.descriptionTarget Lupus Public Patient Involvement and Engagement Group University of Liverpool Faculty of Health and Life Sciences-
Descrição: dc.descriptionDepartment of Pediatric Rheumatology The Children's Hospital of Philadelphia-
Descrição: dc.descriptionCentre for Adolescent Rheumatology Versus Arthritis Division of Medicine University College London-
Descrição: dc.descriptionDepartment of Paediatric Rheumatology Erasmus Medical Center-
Descrição: dc.descriptionDepartment of Pediatric Rheumatology The Hospital for Sick Children-
Descrição: dc.descriptionDepartment of Pediatric Rheumatology University of Toronto-
Descrição: dc.descriptionNational Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases Systemic Autoimmunity Branch-
Descrição: dc.descriptionDepartment of Rheumatology Monash University-
Descrição: dc.descriptionDepartment of Pediatrics Division of Rheumatology Hacettepe University Faculty of Medicine-
Descrição: dc.descriptionDirezione Scientifica Istituto Giannina Gaslini Istituto Pediatrico di Ricovero e Cura A Carattere Scientifico, Liguria-
Descrição: dc.descriptionDipto. di Neuroscienze Riabilitazione Oftalmologia Genetica e Scienze Materno Infantili (DINIGMI) Università Degli Studi di Genova-
Descrição: dc.descriptionDepartment of Pediatric Rheumatology Botucatu Medical School Sao Paulo University Faculty of Medicine-
Descrição: dc.descriptionDepartment of Paediatric Rheumatology Great Ormond Street Hospital for Children-
Descrição: dc.descriptionDepartment of Pediatric Immunology Rheumatology and Infectious Diseases University of Amsterdam-
Descrição: dc.descriptionEmma Children's Hospital Amsterdam University Medical Centres-
Descrição: dc.descriptionDepartment of Paediatric Rheumatology University of Cape Town, Western Cape-
Descrição: dc.descriptionDepartment of Paediatric Nephrology Great Ormond Street Hospital for Children-
Descrição: dc.descriptionDepartment of Pediatric Rheumatology Botucatu Medical School Sao Paulo University Faculty of Medicine-
Formato: dc.format788-798-
Idioma: dc.languageen-
Relação: dc.relationAnnals of the Rheumatic Diseases-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAutoimmune Diseases-
Palavras-chave: dc.subjectGlucocorticoids-
Palavras-chave: dc.subjectHealth services research-
Palavras-chave: dc.subjectLupus Erythematosus, Systemic-
Palavras-chave: dc.subjectOutcome and Process Assessment, Health Care-
Título: dc.titleTowards development of treat to target (T2T) in childhood-onset systemic lupus erythematosus: PReS-endorsed overarching principles and points-to-consider from an international task force-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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