Efficacy and safety of ultra-low-dose estradiol and norethisterone in postmenopausal Brazilian women

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Autor(es): dc.contributorJundiai School of Medicine-
Autor(es): dc.contributorABC School of Medicine-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorCEPIC-
Autor(es): dc.contributorPUC-RS-
Autor(es): dc.contributorUFRGS–Federal University of Rio Grande do Sul-
Autor(es): dc.contributorLibbs Farmacêutica Ltda-
Autor(es): dc.creatorBonassi Machado, R.-
Autor(es): dc.creatorPompei, L. de Melo-
Autor(es): dc.creatorNahas, E. A.P.-
Autor(es): dc.creatorNahas-Neto, J.-
Autor(es): dc.creatorCosta-Paiva, L. da-
Autor(es): dc.creatorDel Debbio, S. Y.O.-
Autor(es): dc.creatorBadalotti, M.-
Autor(es): dc.creatorWender, M. C.O.-
Autor(es): dc.creatorCruz, A. M.-
Data de aceite: dc.date.accessioned2025-08-21T21:05:51Z-
Data de disponibilização: dc.date.available2025-08-21T21:05:51Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/13697137.2023.2190507-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248661-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248661-
Descrição: dc.descriptionObjective: This study aimed to evaluate the efficacy and safety of oral ultra-low-dose continuous combination of 17β-estradiol (17β-E2) and norethisterone acetate (NETA) in postmenopausal Brazilian women. Methods: Postmenopausal women (age 45–60 years) with amenorrhea >12 months and intact uterus, with moderate to severe vasomotor symptoms, were included. The vasomotor symptoms and endometrial bleeding were evaluated by a daily diary for 24 weeks, and the women were assessed at baseline and endpoint. Results: A total of 118 women were included. The group treated with 0.5 mg 17β-E2/0.1 mg NETA (n = 58) showed a percentage reduction of 77.1% in the frequency of vasomotor symptoms versus 49.9% in the placebo group (n = 60) (p = 0.0001). The severity score showed a reduction in the treatment group when compared to the placebo (p < 0.0001). The adverse events were comparable between the groups; however, in the 0.5 mg 17β-E2/0.1 mg NETA group there were more complaints of vaginal bleeding; despite that, in most cycles in both treatment groups, more than 80% of women experienced amenorrhea. Conclusions: The combination of 0.5 mg 17β-E2/0.1 mg NETA in a continuous combination regimen was shown to be effective in reducing the frequency and severity of vasomotor symptoms in Brazilian postmenopausal women.-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Jundiai School of Medicine-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics ABC School of Medicine-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu School of Medicine UNESP–Sao Paulo State University-
Descrição: dc.descriptionDepartment of Obstetrics and Gynecology State University of Campinas-
Descrição: dc.descriptionPaulista Center for Clinical Research CEPIC-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics PUC-RS-
Descrição: dc.descriptionDepartment of Obstetrics and Gynecology School of Medicine UFRGS–Federal University of Rio Grande do Sul-
Descrição: dc.descriptionDepartment of Clinical Research Libbs Farmacêutica Ltda-
Descrição: dc.descriptionDepartment of Gynecology and Obstetrics Botucatu School of Medicine UNESP–Sao Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationClimacteric-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectefficacy-
Palavras-chave: dc.subjecthormone therapy-
Palavras-chave: dc.subjectPostmenopausal women-
Palavras-chave: dc.subjectsafety-
Palavras-chave: dc.subjectultra-low-dose estradiol-
Título: dc.titleEfficacy and safety of ultra-low-dose estradiol and norethisterone in postmenopausal Brazilian women-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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