High prevalence of olfactory impairment among leprosy patients: A cross-sectional study

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Autor(es): dc.contributorUniversidade Estadual de Londrina (UEL)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPontifícia Universidade Católica do Paraná-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Pennsylvania-
Autor(es): dc.creatorKondo, Rogério Nabor-
Autor(es): dc.creatorde Araújo, Milene Cripa Pizatto-
Autor(es): dc.creatorRamos, Paulo Muller-
Autor(es): dc.creatorMiot, Hélio Amante-
Autor(es): dc.creatorFornazieri, Marco Aurélio-
Data de aceite: dc.date.accessioned2025-08-21T18:16:36Z-
Data de disponibilização: dc.date.available2025-08-21T18:16:36Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/journal.pntd.0010888-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248646-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248646-
Descrição: dc.descriptionBackground The effect of leprosy on the sense of smell is not yet fully established. Studies that have relied only on patients’ perceptions may have under-or over-estimated the change in smell perception. A validated and psychophysical method is necessary to avoid these errors in assessment. Objectives This study aimed to validate the existence of olfactory involvement in leprosy patients. Methods A cross-sectional, controlled study was conducted, in which individuals with leprosy (exposed individuals) and individuals without leprosy (control patients) were recruited. For each exposed individual, we selected two control patients. A total of 108 patients (72 control patients and 36 exposed individuals) with no history of infection with the new coronavirus (COVID-19) took the University of Pennsylvania Smell Identification Test (UPSIT). Results Most exposed individuals had olfactory dysfunction [n = 33, 91.7% (CI 95%: 77.5%–98.3%)] when compared with the control patients [n = 28, 38.9% (CI 95%: 27.6%-51.1%)], but only two (5.6%) had olfactory complaints. The olfactory function was significantly worse among exposed individuals [UPSIT leprosy = 25.2 (CI 95%: 23.1–27.3) when compared with the UPSIT control patients = 34.1 (CI 95%: 33.0–35.3); p<0.001]. The risk of olfactory loss was higher among the exposed individuals [OR: 19.5 (CI 95%: 5.18–105.70; p < 0.001)]. Conclusions Olfactory dysfunction was highly prevalent among exposed individuals, although they had little or no self-knowledge of the disorder. The results show that it is important to assess the sense of smell in exposed individuals.-
Descrição: dc.descriptionClinical Medicine Department Dermatology Universidade Estadual de Londrina, Paraná-
Descrição: dc.descriptionDermatology Department of São Paulo State University, São Paulo-
Descrição: dc.descriptionDepartment of Clinical Surgery Universidade Estadual de Londrina, Paraná-
Descrição: dc.descriptionDepartment of Medicine Pontifícia Universidade Católica do Paraná, Paraná-
Descrição: dc.descriptionDepartment of Otorhinolaryngolgy Universidade de São Paulo-
Descrição: dc.descriptionSmell and Test Center Department of Otorhinolaryngology–Head and Neck Surgery Perelman School of Medicine University of Pennsylvania-
Descrição: dc.descriptionDermatology Department of São Paulo State University, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationPLoS Neglected Tropical Diseases-
???dc.source???: dc.sourceScopus-
Título: dc.titleHigh prevalence of olfactory impairment among leprosy patients: A cross-sectional study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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