Amyloid-polysaccharide interfacial coacervates as therapeutic materials

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Autor(es): dc.contributorETH Zurich-
Autor(es): dc.contributorPaul Scherrer Institute PSI-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorPeydayesh, Mohammad-
Autor(es): dc.creatorKistler, Sabrina-
Autor(es): dc.creatorZhou, Jiangtao-
Autor(es): dc.creatorLutz-Bueno, Viviane-
Autor(es): dc.creatorVictorelli, Francesca Damiani-
Autor(es): dc.creatorMeneguin, Andréia Bagliotti-
Autor(es): dc.creatorSpósito, Larissa-
Autor(es): dc.creatorBauab, Tais Maria-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorMezzenga, Raffaele-
Data de aceite: dc.date.accessioned2025-08-21T20:25:00Z-
Data de disponibilização: dc.date.available2025-08-21T20:25:00Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41467-023-37629-z-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248639-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248639-
Descrição: dc.descriptionCoacervation via liquid-liquid phase separation provides an excellent opportunity to address the challenges of designing nanostructured biomaterials with multiple functionalities. Protein-polysaccharide coacervates, in particular, offer an appealing strategy to target biomaterial scaffolds, but these systems suffer from the low mechanical and chemical stabilities of protein-based condensates. Here we overcome these limitations by transforming native proteins into amyloid fibrils and demonstrate that the coacervation of cationic protein amyloids and anionic linear polysaccharides results in the interfacial self-assembly of biomaterials with precise control of their structure and properties. The coacervates present a highly ordered asymmetric architecture with amyloid fibrils on one side and the polysaccharide on the other. We demonstrate the excellent performance of these coacervates for gastric ulcer protection by validating via an in vivo assay their therapeutic effect as engineered microparticles. These results point at amyloid-polysaccharides coacervates as an original and effective biomaterial for multiple uses in internal medicine.-
Descrição: dc.descriptionETH Zurich Department of Health Sciences and Technology-
Descrição: dc.descriptionETH Zurich Department of Materials-
Descrição: dc.descriptionPaul Scherrer Institute PSI-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University, Sao Paulo-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Sciences São Paulo State University, Sao Paulo-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University, Sao Paulo-
Descrição: dc.descriptionDepartment of Biological Sciences School of Pharmaceutical Sciences São Paulo State University, Sao Paulo-
Idioma: dc.languageen-
Relação: dc.relationNature Communications-
???dc.source???: dc.sourceScopus-
Título: dc.titleAmyloid-polysaccharide interfacial coacervates as therapeutic materials-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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