A new complex of silver(I) with probenecid: Synthesis, characterization, and studies of antibacterial and extended spectrum β-lactamases (ESBL) inhibition activities

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorLaboratory of Bacterial Cellulose and Medicinal Chemistry (CBQUIM)-
Autor(es): dc.contributorFederal University of Tocantins-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorDonostia International Physics Center-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorLustri, Wilton R.-
Autor(es): dc.creatorLazarini, Silmara C.-
Autor(es): dc.creatorSimei Aquaroni, Nayara Ap.-
Autor(es): dc.creatorResende, Flávia A.-
Autor(es): dc.creatorAleixo, Nadia A.-
Autor(es): dc.creatorPereira, Douglas H.-
Autor(es): dc.creatorLustri, Bruna Cardinali-
Autor(es): dc.creatorMoreira, Cristiano Gallina-
Autor(es): dc.creatorRibeiro, Camila M.-
Autor(es): dc.creatorPavan, Fernando R.-
Autor(es): dc.creatorNakahata, Douglas H.-
Autor(es): dc.creatorGonçalves, Adriano M.-
Autor(es): dc.creatorNascimento-Júnior, Nailton M.-
Autor(es): dc.creatorCorbi, Pedro P.-
Data de aceite: dc.date.accessioned2025-08-21T21:29:35Z-
Data de disponibilização: dc.date.available2025-08-21T21:29:35Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jinorgbio.2023.112201-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248615-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248615-
Descrição: dc.descriptionThis article describes the in vitro antibacterial and β-lactamase inhibition of a novel silver(I) complex with the sulfonamide probenecid (Ag-PROB). The formula Ag2C26H36N2O8S2·2H2O for the Ag-PROB complex was proposed based on elemental analysis. High-resolution mass spectrometric studies revealed the existence of the complex in its dimeric form. Infrared, nuclear magnetic resonance spectroscopies and Density Functional Theory calculations indicated a bidentate coordination of probenecid to the silver ions by the oxygen atoms of the carboxylate. In vitro antibacterial activities of Ag-PROB showed significant growth inhibitory activity over Mycobacterium tuberculosis, S. aureus, and P. aeruginosa PA01biofilm-producers, B. cereus, and E. coli. The Ag-PROB complex was active over multi-drug resistant of uropathogenic E. coli extended spectrum β-lactamases (ESBL) producing (EC958 and BR43), enterohemorrhagic E. coli (O157:H7) and enteroaggregative E. coli (O104:H4). Ag-PROB was able to inhibit CTX-M-15 and TEM-1B ESBL classes, at concentrations below the minimum inhibitory concentration for Ag-PROB, in the presence of ampicillin (AMP) concentration in which EC958 and BR43 bacteria were resistant in the absence of Ag-PROB. These results indicate that, in addition to ESBL inhibition, there is a synergistic antibacterial effect between AMP and the Ag-PROB. Molecular docking results revealed potential key residues involved in interactions between Ag-PROB, CTX-M-15 and TEM[sbnd]1B, suggesting the molecular mechanism of the ESBL inhibition. The obtained results added to the absence of mutagenic activity and low cytotoxic activity over non-tumor cell of the Ag-PROB complex open a new perspective for future in vivo tests demonstrating its potential of use as an antibacterial agent.-
Descrição: dc.descriptionASCRS Research Foundation-
Descrição: dc.descriptionDepartment of Biological and Health Sciences - University of Araraquara - UNIARA Laboratory of Bacterial Cellulose and Medicinal Chemistry (CBQUIM), São Paulo-
Descrição: dc.descriptionChemistry Collegiate Federal University of Tocantins, Campus Gurupi-Badejós, PO Box 66-
Descrição: dc.descriptionInstitute of Chemistry University of Campinas – UNICAMP, São Paulo-
Descrição: dc.descriptionDonostia International Physics Center, Paseo Manuel de Lardizabal 4-
Descrição: dc.descriptionSão Paulo State University – UNESP School of Pharmaceutical Sciences-
Descrição: dc.descriptionSão Paulo State University (Unesp) Institute of Chemistry Department of Biochemistry and Organic Chemistry Laboratory of Medicinal Chemistry Organic Synthesis and Molecular Modeling (LaQMedSOMM), São Paulo-
Descrição: dc.descriptionSão Paulo State University – UNESP School of Pharmaceutical Sciences-
Descrição: dc.descriptionSão Paulo State University (Unesp) Institute of Chemistry Department of Biochemistry and Organic Chemistry Laboratory of Medicinal Chemistry Organic Synthesis and Molecular Modeling (LaQMedSOMM), São Paulo-
Descrição: dc.descriptionASCRS Research Foundation: 2015/09833-0-
Descrição: dc.descriptionASCRS Research Foundation: 2015/20882-3-
Descrição: dc.descriptionASCRS Research Foundation: 2017/16278-9-
Descrição: dc.descriptionASCRS Research Foundation: 2017/19243-1-
Descrição: dc.descriptionASCRS Research Foundation: 2017/24914-2-
Descrição: dc.descriptionASCRS Research Foundation: 2018/00163-0-
Descrição: dc.descriptionASCRS Research Foundation: 2018/00187-7-
Descrição: dc.descriptionASCRS Research Foundation: 2018/02344-2-
Descrição: dc.descriptionASCRS Research Foundation: 2018/12062-4-
Descrição: dc.descriptionASCRS Research Foundation: 2018/12590-0-
Descrição: dc.descriptionASCRS Research Foundation: 2019/03049-7-
Descrição: dc.descriptionASCRS Research Foundation: 2019/26696-8-
Descrição: dc.descriptionASCRS Research Foundation: 2020/13497-4-
Descrição: dc.descriptionASCRS Research Foundation: 2021/07458-9-
Descrição: dc.descriptionASCRS Research Foundation: 2021/08717-8-
Idioma: dc.languageen-
Relação: dc.relationJournal of Inorganic Biochemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntibacterial agent-
Palavras-chave: dc.subjectMolecular docking-
Palavras-chave: dc.subjectMulti-drug resistant-
Palavras-chave: dc.subjectProbenecid-
Palavras-chave: dc.subjectSilver complex-
Palavras-chave: dc.subjectβ-lactamase inhibition-
Título: dc.titleA new complex of silver(I) with probenecid: Synthesis, characterization, and studies of antibacterial and extended spectrum β-lactamases (ESBL) inhibition activities-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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