Anti-Inflammatory Effect and Toxicological Profile of Pulp Residue from the Caryocar Brasiliense, a Sustainable Raw Material

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorNossa Senhora do Patrocínio Faculty Center—CEUNSP-
Autor(es): dc.creatorFracasso, Julia Amanda Rodrigues-
Autor(es): dc.creatorIbe, Mariana Bittencourt-
Autor(es): dc.creatorda Costa, Luísa Taynara Silvério-
Autor(es): dc.creatorGuarnier, Lucas Pires-
Autor(es): dc.creatorViel, Amanda Martins-
Autor(es): dc.creatorBrito, Gustavo Reis de-
Autor(es): dc.creatorParron, Mariana Conti-
Autor(es): dc.creatorPereira, Anderson Espírito do Santo-
Autor(es): dc.creatorPegorin Brasil, Giovana Sant’Ana-
Autor(es): dc.creatorFarias Ximenes, Valdecir-
Autor(es): dc.creatorFraceto, Leonardo Fernandes-
Autor(es): dc.creatorMalacrida Mayer, Cassia Roberta-
Autor(es): dc.creatorRibeiro-Paes, João Tadeu-
Autor(es): dc.creatorFerreira, Fernando Yutaka de-
Autor(es): dc.creatorZoppe, Natália Alves-
Autor(es): dc.creatorSantos, Lucinéia dos-
Data de aceite: dc.date.accessioned2025-08-21T15:16:37Z-
Data de disponibilização: dc.date.available2025-08-21T15:16:37Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/gels9030234-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248611-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248611-
Descrição: dc.descriptionCaryocar brasiliense Cambess is a plant species typical of the Cerrado, a Brazilian biome. The fruit of this species is popularly known as pequi, and its oil is used in traditional medicine. However, an important factor hindering the use of pequi oil is its low yield when extracted from the pulp of this fruit. Therefore, in this study, with aim of developing a new herbal medicine, we an-alyzed the toxicity and anti-inflammatory activity of an extract of pequi pulp residue (EPPR), fol-lowing the mechanical extraction of the oil from its pulp. For this purpose, EPPR was prepared and encapsulated in chitosan. The nanoparticles were analyzed, and the cytotoxicity of the encapsu-lated EPPR was evaluated in vitro. After confirming the cytotoxicity of the encapsulated EPPR, the following evaluations were performed with non-encapsulated EPPR: in vitro anti-inflammatory activity, quantification of cytokines, and acute toxicity in vivo. Once the anti-inflammatory activity and absence of toxicity of EPPR were verified, a gel formulation of EPPR was developed for topical use and analyzed for its in vivo anti-inflammatory potential, ocular toxicity, and previous stability assessment. EPPR and the gel containing EPPR showed effective anti-inflammatory activity and lack of toxicity. The formulation was stable. Thus, a new herbal medicine with anti-inflammatory activity can be developed from discarded pequi residue.-
Descrição: dc.descriptionSchool of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biotechnology School of Sciences and Languages São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biotechnology and Bioprocesses Engineering School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Genetics Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionNossa Senhora do Patrocínio Faculty Center—CEUNSP-
Descrição: dc.descriptionDepartment of Biology School of Sciences and Languages São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Science and Technology of Sorocaba São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biochemistry and Chemical Technology Institute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Chemistry Faculty of Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biotechnology School of Sciences and Languages São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biotechnology and Bioprocesses Engineering School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biology School of Sciences and Languages São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Science and Technology of Sorocaba São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biochemistry and Chemical Technology Institute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Chemistry Faculty of Sciences São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationGels-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCerrado-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectnanotechnology-
Palavras-chave: dc.subjectpequi-
Palavras-chave: dc.subjectphytotherapic-
Título: dc.titleAnti-Inflammatory Effect and Toxicological Profile of Pulp Residue from the Caryocar Brasiliense, a Sustainable Raw Material-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.