Oxazolidinones as versatile scaffolds in medicinal chemistry

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity College London-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorKing's College London-
Autor(es): dc.creatorFernandes, Guilherme Felipe Santos-
Autor(es): dc.creatorScarim, Cauê Benito-
Autor(es): dc.creatorKim, Seong-Heun-
Autor(es): dc.creatorWu, Jingyue-
Autor(es): dc.creatorCastagnolo, Daniele-
Data de aceite: dc.date.accessioned2025-08-21T18:28:41Z-
Data de disponibilização: dc.date.available2025-08-21T18:28:41Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-02-07-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1039/d2md00415a-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248603-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248603-
Descrição: dc.descriptionOxazolidinone is a five-member heterocyclic ring with several biological applications in medicinal chemistry. Among the three possible isomers, 2-oxazolidinone is the most investigated in drug discovery. Linezolid was pioneered as the first approved drug containing an oxazolidinone ring as the pharmacophore group. Numerous analogues have been developed since its arrival on the market in 2000. Some have succeeded in reaching the advanced stages of clinical studies. However, most oxazolidinone derivatives reported in recent decades have not reached the initial stages of drug development, despite their promising pharmacological applications in a variety of therapeutic areas, including antibacterial, antituberculosis, anticancer, anti-inflammatory, neurologic, and metabolic diseases, among other areas. Therefore, this review article aims to compile the efforts of medicinal chemists who have explored this scaffold over the past decades and highlight the potential of the class for medicinal chemistry.-
Descrição: dc.descriptionHorizon 2020-
Descrição: dc.descriptionDepartment of Chemistry University College London, 20 Gordon Street-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University-
Descrição: dc.descriptionSchool of Cancer and Pharmaceutical Sciences King's College London, 150 Stamford Street-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University-
Formato: dc.format823-847-
Idioma: dc.languageen-
Relação: dc.relationRSC Medicinal Chemistry-
???dc.source???: dc.sourceScopus-
Título: dc.titleOxazolidinones as versatile scaffolds in medicinal chemistry-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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