Cytotoxicity and Biomineralization Potential of Flavonoids Incorporated into PNVCL Hydrogels

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversity of Toronto-
Autor(es): dc.creatorBraga, Gabriela Pacheco de Almeida-
Autor(es): dc.creatorCaiaffa, Karina Sampaio-
Autor(es): dc.creatorRabelo, Rafaela Laruzo-
Autor(es): dc.creatorSantos, Vanessa Rodrigues dos-
Autor(es): dc.creatorSouza, Amanda Caselato Andolfatto-
Autor(es): dc.creatorRibeiro, Lucas da Silva-
Autor(es): dc.creatorCamargo, Emerson Rodrigues de-
Autor(es): dc.creatorPrakki, Anuradha-
Autor(es): dc.creatorDuque, Cristiane-
Data de aceite: dc.date.accessioned2025-08-21T21:42:03Z-
Data de disponibilização: dc.date.available2025-08-21T21:42:03Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/jfb14030139-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248591-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248591-
Descrição: dc.descriptionThis study aimed to evaluate the effects of flavonoids incorporated into poly(N-vinylcaprolactam) (PNVCL) hydrogel on cell viability and mineralization markers of odontoblast-like cells. MDPC-23 cells were exposed to ampelopsin (AMP), isoquercitrin (ISO), rutin (RUT) and control calcium hydroxide (CH) for evaluation of cell viability, total protein (TP) production, alkaline phosphatase (ALP) activity and mineralized nodule deposition by colorimetric assays. Based on an initial screening, AMP and CH were loaded into PNVCL hydrogels and had their cytotoxicity and effect on mineralization markers determined. Cell viability was above 70% when MDPC-23 cells were treated with AMP, ISO and RUT. AMP showed the highest ALP activity and mineralized nodule deposition. Extracts of PNVCL+AMP and PNVCL+CH in culture medium (at the dilutions of 1/16 and 1/32) did not affect cell viability and stimulated ALP activity and mineralized nodules’ deposition, which were statistically higher than the control in osteogenic medium. In conclusion, AMP and AMP-loaded PNVCL hydrogels were cytocompatible and able to induce bio-mineralization markers in odontoblast-cells.-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry Araçatuba Dental School São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Chemistry Federal University of São Carlos (UFSCar), SP-
Descrição: dc.descriptionDental Research Institute Faculty of Dentistry University of Toronto-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry Araçatuba Dental School São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationJournal of Functional Biomaterials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectalkaline phosphatase-
Palavras-chave: dc.subjectcytotoxicity-
Palavras-chave: dc.subjectdentin mineralization-
Palavras-chave: dc.subjectflavonoids-
Palavras-chave: dc.subjecthydrogel-
Palavras-chave: dc.subjectodontoblasts-
Título: dc.titleCytotoxicity and Biomineralization Potential of Flavonoids Incorporated into PNVCL Hydrogels-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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