Transcriptomic Profile of Canine Mammary Ductal Carcinoma

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidad de Antioquia (UdeA)-
Autor(es): dc.contributorHospital Veterinário de São Bento-
Autor(es): dc.creatorSantos, Driéle B.-
Autor(es): dc.creatorFernandez, Geysson J.-
Autor(es): dc.creatorPardini, Luciana M. C.-
Autor(es): dc.creatorPardini, Maria Inês M. C.-
Autor(es): dc.creatorFerrasi, Adriana C.-
Data de aceite: dc.date.accessioned2025-08-21T21:49:25Z-
Data de disponibilização: dc.date.available2025-08-21T21:49:25Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms24065212-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248587-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248587-
Descrição: dc.descriptionDogs can be excellent models for spontaneous studies about breast cancers, presenting similarities in clinical behavior and molecular pathways of the disease. Thus, analyses of the canine transcriptome can identify deregulated genes and pathways, contributing to the identification of biomarkers and new therapeutic targets, benefiting humans and animals. In this context, this study aimed to determine the transcriptional profile of canine mammary ductal carcinoma and contribute to the clarification of the importance of deregulated molecules in the molecular pathways involved in the disease. Therefore, we used mammary ductal carcinoma tissue samples and non-tumor mammary tissue from the radical mastectomy of six female dogs. Sequencing was performed on the NextSeq-500 System platform. A comparison of carcinoma tissue and normal tissue revealed 633 downregulated and 573 upregulated genes, which were able to differentiate the groups by principal component analysis. Gene ontology analysis indicated that inflammatory, cell differentiation and adhesion, and extracellular matrix maintenance pathways were mainly deregulated in this series. The main differentially expressed genes observed in this research can indicate greater disease aggressiveness and worse prognosis. Finally, the study of the canine transcriptome indicates that it is an excellent model to generate information relevant to oncology in both species.-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School (FMB) São Paulo State University (UNESP), SP-
Descrição: dc.descriptionGrupo Biologia y Control de Enfermedades Infeciosas (BCEI) Facultad de Ciencias exactas y Naturales Universidad de Antioquia (UdeA)-
Descrição: dc.descriptionHospital Veterinário de São Bento-
Descrição: dc.descriptionDepartment of Internal Medicine Botucatu Medical School (FMB) São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectfemale dogs-
Palavras-chave: dc.subjectmammary ductal carcinoma-
Palavras-chave: dc.subjecttranscriptome-
Título: dc.titleTranscriptomic Profile of Canine Mammary Ductal Carcinoma-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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