Resveratrol for preventing medication-related osteonecrosis of the jaws in rats

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Autor(es): dc.contributorPaulista University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorVitale, Marcelo-
Autor(es): dc.creatorCorrêa, Mônica Grazieli-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorCirano, Fabiano Ribeiro-
Autor(es): dc.creatorRibeiro, Fernanda Vieira-
Autor(es): dc.creatorMonteiro, Mabelle Freitas-
Autor(es): dc.creatorCasati, Marcio Zaffalon-
Autor(es): dc.creatorPimentel, Suzana Peres-
Data de aceite: dc.date.accessioned2025-08-21T22:03:42Z-
Data de disponibilização: dc.date.available2025-08-21T22:03:42Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/odi.14544-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248545-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248545-
Descrição: dc.descriptionThis study evaluated the effect of resveratrol (RES) on the prevention of medication-related osteonecrosis of the jaws (MRONJ) in ovariectomized (OVX) rats treated with zoledronate (ZOL). Fifty rats were distributed in five groups: SHAM (n = 10): non-ovariectomy + placebo; OVX (n = 10):ovariectomy + placebo; OVX + RES (n = 10):ovariectomy + resveratrol; OVX + ZOL (n = 10):ovariectomy + placebo + zoledronate; and OVX + RES + ZOL (n = 10):ovariectomy + resveratrol + zoledronate. The mandibles left sides were analyzed with micro-CT, histomorphometry, and immunohistochemistry. On the right side, bone markers gene expression was analyzed by qPCR. ZOL increased the percentage of necrotic bone and reduced the neo-formed bone compared to groups not receiving ZOL (p < 0.05). RES impacted the tissue healing pattern in OVX + ZOL + RES, reduced inflammatory cell infiltrate, and improved bone formation in the extraction site. Osteoblasts, alkaline phosphatase (ALP)-, and osteocalcin (OCN)-immunoreactive cells were lower in OVX-ZOL than in SHAM, OVX, and OVX-RES. The OXV-ZOL-RES had fewer osteoblasts and ALP- and OCN-cells than the SHAM and OVX-RES. The tartrate-resistant acid phosphatase (TRAP)-positive cells were reduced in the presence of ZOL (p < 0.05), while the TRAP mRNA levels increased with ZOL treatment, with or without resveratrol, compared with the other groups (p < 0.05). RES alone increased superoxide dismutase levels compared to OVX + ZOL and OVX + ZOL + RES (p < 0.05). In conclusion, resveratrol reduced the tissue impairment severity induced by ZOL; however, it could not prevent the occurrence of MRONJ.-
Descrição: dc.descriptionDental Research Division School of Dentistry Paulista University-
Descrição: dc.descriptionDepartment of Basic Sciences Dental School of Araçatuba University Estadual Paulista UNESP-
Descrição: dc.descriptionDepartment of Basic Sciences Dental School of Araçatuba University Estadual Paulista UNESP-
Idioma: dc.languageen-
Relação: dc.relationOral Diseases-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbisphosphonates-
Palavras-chave: dc.subjectosteonecrosis-
Palavras-chave: dc.subjectosteoporosis-
Palavras-chave: dc.subjectovariectomy-
Palavras-chave: dc.subjectresveratrol-
Palavras-chave: dc.subjectzoledronic acid-
Título: dc.titleResveratrol for preventing medication-related osteonecrosis of the jaws in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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