In Vitro Antiglycation Potential of Erva-Baleeira (Varronia curassavica Jacq.)

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorRodrigues, Winner Duque-
Autor(es): dc.creatorCardoso, Felipe Nunes-
Autor(es): dc.creatorBaviera, Amanda Martins-
Autor(es): dc.creatordos Santos, André Gonzaga-
Data de aceite: dc.date.accessioned2025-08-21T15:10:56Z-
Data de disponibilização: dc.date.available2025-08-21T15:10:56Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/antiox12020522-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248449-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248449-
Descrição: dc.descriptionBackground: Varronia curassavica Jacq. (Boraginaceae) is traditionally used in the treatment of inflammatory processes. The ethanolic extract of its leaves (EEVc) showed anti-inflammatory properties and low toxicity. Medicinal plants have aroused interest for their antiglycation activities. The formation and accumulation of advanced glycation end products (AGEs) are associated with several chronic diseases. The objective of this study was to evaluate the antiglycation potential of EEVc and two isolated compounds. Methods: The compounds brickellin and cordialin A were obtained by chromatographic methods and identified by spectrometric techniques. Analysis of fluorescent AGEs, biomarkers of amino acid residue oxidation, protein carbonyl groups and crosslink formation were performed in samples obtained from an in vitro model system of protein glycation with methylglyoxal. Results: EEVc, brickellin and cordialin A significantly reduced the in vitro formation of AGEs, and reduced the damage caused by oxidative damage to the protein. Conclusions: According to the results, EEVc, brickellin and cordialin A are potential candidates against AGEs formation, which opens the way to expand the therapeutic arsenal for many pathologies resulting from glycoxidative stress.-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University-
Descrição: dc.descriptionDepartment of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationAntioxidants-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantiglycation activity-
Palavras-chave: dc.subjectbrickellin-
Palavras-chave: dc.subjectCordia verbenacea-
Palavras-chave: dc.subjectcordialin A-
Palavras-chave: dc.subjectoxidative stress-
Título: dc.titleIn Vitro Antiglycation Potential of Erva-Baleeira (Varronia curassavica Jacq.)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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