Unraveling Hepatic Metabolomic Profiles and Morphological Outcomes in a Hybrid Model of NASH in Different Mouse Strains

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Vrije-
Autor(es): dc.creatorBacil, Gabriel P.-
Autor(es): dc.creatorRomualdo, Guilherme R.-
Autor(es): dc.creatorPiagge, Priscila M. F. D.-
Autor(es): dc.creatorCardoso, Daniel R.-
Autor(es): dc.creatorVinken, Mathieu-
Autor(es): dc.creatorCogliati, Bruno-
Autor(es): dc.creatorBarbisan, Luís F.-
Data de aceite: dc.date.accessioned2025-08-21T20:54:11Z-
Data de disponibilização: dc.date.available2025-08-21T20:54:11Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/antiox12020290-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248444-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248444-
Descrição: dc.descriptionNonalcoholic fatty liver disease (NAFLD) encompasses nonalcoholic steatohepatitis (NASH) and affects 25% of the global population. Although a plethora of experimental models for studying NASH have been proposed, still scarce findings regarding the hepatic metabolomic/molecular profile. In the present study, we sought to unravel the hepatic metabolomic profile of mice subjected to a hybrid model of NASH, by combining a Western diet and carbon tetrachloride administration, for 8 weeks, in male C57BL/6J and BALB/c mice. In both mouse strains, the main traits of NASH—metabolic (glucose intolerance profile), morphologic (extensive microvesicular steatosis and fibrosis, lobular inflammation, and adipose tissue-related inflammation/hypertrophy), and molecular (impaired Nrf2/NF-κB pathway dynamics and altered metabolomic profile)—were observed. The hepatic metabolomic profile revealed that the hybrid protocol impaired, in both strains, the abundance of branched chain-aromatic amino acids, carboxylic acids, and glycosyl compounds, that might be linked to the Nrf2 pathway activation. Moreover, we observed a strain-dependent hepatic metabolomic signature, in which the tricarboxylic acid metabolites and pyruvate metabolism were dissimilarly modulated in C57BL/6J and BALB/c mice. Thus, we provide evidence that the strain-dependent hepatic metabolomic profile might be linked to the distinct underlying mechanisms of NASH, also prospecting potential mechanistic insights into the corresponding disease.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School (FMB) São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Biosciences Institute São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Chemistry and Molecular Physics São Carlos Institute of Chemistry (IQSC) University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Pharmaceutical and Pharmacological Sciences University of Vrije-
Descrição: dc.descriptionDepartment of Pathology School of Veterinary Medicine and Animal Science University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School (FMB) São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Biosciences Institute São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: #2017/01189-0-
Descrição: dc.descriptionFAPESP: #2020/01078-7-
Descrição: dc.descriptionCNPq: #309212/2019-7-
Idioma: dc.languageen-
Relação: dc.relationAntioxidants-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcarbon tetrachloride-
Palavras-chave: dc.subjectmetabolomic profile-
Palavras-chave: dc.subjectnonalcoholic fatty liver disease-
Palavras-chave: dc.subjectnonalcoholic steatohepatitis-
Palavras-chave: dc.subjectwestern diet-
Título: dc.titleUnraveling Hepatic Metabolomic Profiles and Morphological Outcomes in a Hybrid Model of NASH in Different Mouse Strains-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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