Severe Diabetes Induction as a Generational Model for Growth Restriction of Rat

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Mato Grosso (UFMT)-
Autor(es): dc.contributorInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán-
Autor(es): dc.creatorda Cruz, Larissa Lopes-
Autor(es): dc.creatorBarco, Vinícius Soares-
Autor(es): dc.creatorPaula, Verônyca Gonçalves-
Autor(es): dc.creatorGallego, Franciane Quintanilha-
Autor(es): dc.creatorSouza, Maysa Rocha-
Autor(es): dc.creatorCorrente, José Eduardo-
Autor(es): dc.creatorZambrano, Elena-
Autor(es): dc.creatorVolpato, Gustavo Tadeu-
Autor(es): dc.creatorDamasceno, Débora Cristina-
Data de aceite: dc.date.accessioned2025-08-21T19:18:22Z-
Data de disponibilização: dc.date.available2025-08-21T19:18:22Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s43032-023-01198-9-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248430-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248430-
Descrição: dc.descriptionWe used uncontrolled maternal diabetes as a model to provoke fetal growth restriction in the female in the first generation (F1) and to evaluate reproductive outcomes and the possible changes in metabolic systems during pregnancy, as well as the repercussions at birth in the second generation (F2). For this, nondiabetic and streptozotocin-induced severely diabetic Sprague-Dawley rats were mated to obtain female pups (F1), which were classified as adequate (AGA) or small (SGA) for gestational weight. Afterward, we composed two groups: F1 AGA from nondiabetic dams (Control) and F1 SGA from severely diabetic dams (Restricted) (n minimum = 10 animals/groups). At adulthood, these rats were submitted to the oral glucose tolerance test, mated, and at day 17 of pregnancy, blood samples were collected to determine glucose and insulin levels for assessment of insulin resistance. At the end of the pregnancy, the blood and liver samples were collected to evaluate redox status markers, and reproductive, fetal, and placental outcomes were analyzed. Maternal diabetes was responsible for increased SGA rates and a lower percentage of AGA fetuses (F1 generation). The restricted female pups from severely diabetic dams presented rapid neonatal catch-up growth, glucose intolerance, and insulin resistance status before and during pregnancy. At term pregnancy of F1 generation, oxidative stress status was observed in the maternal liver and blood samples. In addition, their offspring (F2 generation) had lower fetal weight and placental efficiency, regardless of gender, which caused fetal growth restriction and confirmed the fetal programming influence.-
Descrição: dc.descriptionPostgraduate Course on Tocogynecology Laboratory of Experimental Research on Gynecology and Obstetrics Botucatu Medical School São Paulo State University (UNESP), São Paulo State-
Descrição: dc.descriptionInstitute of Biological and Health Sciences Laboratory of System Physiology and Reproductive Toxicology Federal University of Mato Grosso (UFMT), Mato Grosso State-
Descrição: dc.descriptionResearch Support Office Botucatu Medical School Sao Paulo State University (UNESP), São Paulo State-
Descrição: dc.descriptionInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Department of Reproductive Biology-
Descrição: dc.descriptionPostgraduate Course on Tocogynecology Laboratory of Experimental Research on Gynecology and Obstetrics Botucatu Medical School São Paulo State University (UNESP), São Paulo State-
Descrição: dc.descriptionResearch Support Office Botucatu Medical School Sao Paulo State University (UNESP), São Paulo State-
Idioma: dc.languageen-
Relação: dc.relationReproductive Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnimal models-
Palavras-chave: dc.subjectFetal programming-
Palavras-chave: dc.subjectHyperglycemia-
Palavras-chave: dc.subjectLow birth weight-
Palavras-chave: dc.subjectMalondialdehyde-
Palavras-chave: dc.subjectPregnancy-
Título: dc.titleSevere Diabetes Induction as a Generational Model for Growth Restriction of Rat-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.