Evaluation of Vitamin D isolated or Associated with Teriparatide in Peri-Implant Bone Repair in Tibia of Orchiectomized Rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorMcMaster University-
Autor(es): dc.creatorGomes-Ferreira, Pedro Henrique Silva-
Autor(es): dc.creatorFrigério, Paula Buzo-
Autor(es): dc.creatorde Moura, Juliana-
Autor(es): dc.creatorDuarte, Nathália Dantas-
Autor(es): dc.creatorde Oliveira, Danila-
Autor(es): dc.creatorDeering, Joseph-
Autor(es): dc.creatorGrandfield, Kathryn-
Autor(es): dc.creatorOkamoto, Roberta-
Data de aceite: dc.date.accessioned2025-08-21T17:47:54Z-
Data de disponibilização: dc.date.available2025-08-21T17:47:54Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/biology12020228-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248422-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248422-
Descrição: dc.description(1) Background: The objective of this study was to evaluate the morphometry of peri-implant bone tissue in orchiectomized rats, treated with vitamin D isolated or associated with teriparatide. (2) Methods: 24 rats were divided into 4 groups: ORQ—orchiectomy, without drug treatment, ORQ+D—orchiectomy, treated with vitamin D, ORQTERI—orchiectomy, treated with teriparatide and ORQTERI+D—orchiectomy, treated with teriparatide + vitamin D. Each animal received an implant in the tibial metaphysis. Euthanasia occurred 60 days after implant surgery. Computed microtomography (micro-CT) was performed to evaluate the parameters of volume and percentage of bone volume (BV, BV/TV), trabecular thickness (Tb.Th), number and separation of trabeculae (Tb.N, Tb.Sp) and percentage of total porosity (Po-tot). Data were subjected to 1-way ANOVA and Tukey post-test, with a significance level of 5%. (3) Results: For the parameters BV, BV/TV, Tb.Th, the ORQTERI+D group showed the highest values in relation to the other groups and for Po-tot, the lowest values were for ORQTERI+D. For Tb.Sp and Tb.N, there was no statistically significant difference when comparing intragroup results (p > 0.05). (4) Conclusions: It was possible to conclude that treatment with vitamin D associated with teriparatide increases bone volume and improves bone quality.-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESP-
Descrição: dc.descriptionDepartment of Basic Sciences Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESP-
Descrição: dc.descriptionDepartment of Materials Science and Engineering McMaster University-
Descrição: dc.descriptionSchool of Biomedical Engineering McMaster University-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESP-
Descrição: dc.descriptionDepartment of Basic Sciences Araçatuba Dental School São Paulo State University Júlio de Mesquita Filho—UNESP-
Idioma: dc.languageen-
Relação: dc.relationBiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectdental implants-
Palavras-chave: dc.subjectmen-
Palavras-chave: dc.subjectosteoporosis-
Palavras-chave: dc.subjectteriparatide-
Palavras-chave: dc.subjectvitamin D-
Título: dc.titleEvaluation of Vitamin D isolated or Associated with Teriparatide in Peri-Implant Bone Repair in Tibia of Orchiectomized Rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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