Antimicrobial activity of water-soluble tetra-cationic porphyrins on Pseudomonas aeruginosa

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Autor(es): dc.contributorUniversidade Federal de Santa Maria-
Autor(es): dc.contributorUniversidade Federal de Sergipe (UFS)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorUrquhart, Carolina Gonzalez-
Autor(es): dc.creatorPinheiro, Ticiane da Rosa-
Autor(es): dc.creatorda Silva, Jean Lucas Gutknecht-
Autor(es): dc.creatorLeal, Daniela Bitencourt Rosa-
Autor(es): dc.creatorBurgo, Thiago Augusto Lima-
Autor(es): dc.creatorIglesias, Bernardo Almeida-
Autor(es): dc.creatorSantos, Roberto Christ Vianna-
Data de aceite: dc.date.accessioned2025-08-21T16:20:42Z-
Data de disponibilização: dc.date.available2025-08-21T16:20:42Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.pdpdt.2022.103266-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248421-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248421-
Descrição: dc.descriptionThis manuscript presents the cytotoxicity, antimicrobial activity, antibiofilm preliminary properties, and associated therapy with commercial drugs using water-soluble tetra-cationic porphyrins against Pseudomonas aeruginosa. Two commercial tetra-cationic porphyrins were tested against a standard strain of P. aeruginosa 01 (PA01) in antibacterial activity assays under dark conditions and irradiated with white light for 120 min. Porphyrin 4-H2TMePor showed better antimicrobial activity and was chosen for further tests. Increased minimum inhibitory concentration was observed in the presence of reactive oxygen species, suggesting that photooxidation was mediated by the singlet oxygen production. In the time-kill curve assay, 4-H2TMePor inhibited bacterial growth in 90 min of irradiation. The checkerboard assay revealed synergistic interactions. Biofilms of the standard PA01 strain and three clinical isolates were formed. The biofilm destruction assay was more efficient for PA01, significantly reducing the biofilm biomass formed compared to the positive control. The associated treatment to destroy the biofilm potentiated a significant decrease in the biofilm biomass compared to the positive control. The photosensitizer did not damage human keratinocytes or mouse fibroblasts in the cytotoxicity assays, demonstrating the safety of using 4-H2TMePor. Atomic force microscopy indicated lower adhesion force, higher cell wall deformation, and higher dissipation energy in the treated control compared to untreated PA01. Given our findings, it is evident that water-soluble tetra-cationic porphyrins have excellent antimicrobial and a preliminary antibiofilm activity against Gram-negative bacteria, proving to be a potential photosensitizer for clinical use.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado do Rio Grande do Sul-
Descrição: dc.descriptionPrograma de Pós-Graduação em Ciências Farmacêuticas Centro de Ciências da Saúde Departamento de Microbiologia e Parasitologia (LAPEMICRO) Universidade Federal de Santa Maria, RS-
Descrição: dc.descriptionLaboratório de Imunologia Experimental e Aplicada (LABIBIO) Universidade Federal de Santa Maria (UFSM), RS-
Descrição: dc.descriptionDepartment of Chemistry and Environmental Sciences Ibilce Sao Paulo State University (Unesp), R. Cristovao Colombo, 2265, SP-
Descrição: dc.descriptionLaboratório de Bioinorgânica e Materiais Porfirínicos (LBMP) Departamento de Química Universidade Federal de Santa Maria (UFSM), RS-
Descrição: dc.descriptionDepartment of Chemistry and Environmental Sciences Ibilce Sao Paulo State University (Unesp), R. Cristovao Colombo, 2265, SP-
Descrição: dc.descriptionFAPESP: 2014/50906-9-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado do Rio Grande do Sul: PQ-Gaúcho 21/2551-0002114-4-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado do Rio Grande do Sul: PqG – 17/2551-0001075-2-
Idioma: dc.languageen-
Relação: dc.relationPhotodiagnosis and Photodynamic Therapy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntibiofilm activity-
Palavras-chave: dc.subjectCheckerboard-
Palavras-chave: dc.subjectGram-negative-
Palavras-chave: dc.subjectPhotodynamic therapy-
Palavras-chave: dc.subjectPhotoinactivation-
Título: dc.titleAntimicrobial activity of water-soluble tetra-cationic porphyrins on Pseudomonas aeruginosa-
Tipo de arquivo: dc.typelivro digital-
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