Effects of exposure to sediment-associated fipronil on cardiac function of Neotropical armored catfish Hypostomus regani

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.creatorFerro, Lucas Abreu-
Autor(es): dc.creatorFernandes, Suzana Luisa Alves-
Autor(es): dc.creatorKalinin, Ana Lúcia-
Autor(es): dc.creatorMonteiro, Diana Amaral-
Data de aceite: dc.date.accessioned2025-08-21T16:14:58Z-
Data de disponibilização: dc.date.available2025-08-21T16:14:58Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/10934529.2023.2182582-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248400-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248400-
Descrição: dc.descriptionFipronil is widely used as a broad-spectrum insecticide in agriculture, urban environments, and veterinary medicine. Fipronil can enter aquatic ecosystems and spread to sediment and organic matter, representing a risk to non-target species. This study aimed to evaluate the effects of short-term (96 h) exposure to a low and realistic concentration of sediment-associated fipronil (4.2 µg.kg−1 of Regent® 800 WG) on myocardial contractility of armored catfish Hypostomus regain, a benthic fish species. Fipronil exposure induced increased inotropism and acceleration of contractile kinetics, although no alterations in the relative ventricular mass were observed. This better cardiac function was associated with an elevated expression and/or function of the Na+/Ca2+ exchanger and its marked contribution to contraction and relaxation, probably due to a stress-induced adrenergic stimulation. Ventricle strips of exposed fish also exhibited a faster relaxation and a higher cardiac pumping capacity, indicating that armored catfish were able to perform cardiac adjustments to face the exposure. However, a high energetic cost to maintain an increased cardiac performance can make fish more susceptible to other stressors, impairing developmental processes and/or survival. These findings highlight the need for regulations of emerging contaminants, such as fipronil, to ensure adequate protection of the aquatic system.-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences Federal University of São Carlos (UFSCar) São Paulo State University (UNESP), Araraquara-
Descrição: dc.descriptionDepartment of Physiological Sciences Federal University of São Carlos (UFSCar), São Paulo-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences Federal University of São Carlos (UFSCar) São Paulo State University (UNESP), Araraquara-
Formato: dc.format236-245-
Idioma: dc.languageen-
Relação: dc.relationJournal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcalcium handling-
Palavras-chave: dc.subjectcardiac pumping capacity-
Palavras-chave: dc.subjectcontaminated sediments-
Palavras-chave: dc.subjectcontractile force-
Palavras-chave: dc.subjectexcitation-contraction coupling-
Palavras-chave: dc.subjectfish-
Palavras-chave: dc.subjectheart-
Palavras-chave: dc.subjectInsecticide-
Palavras-chave: dc.subjectNa+/Ca2+ exchanger-
Palavras-chave: dc.subjectphysiological biomarkers-
Título: dc.titleEffects of exposure to sediment-associated fipronil on cardiac function of Neotropical armored catfish Hypostomus regani-
Tipo de arquivo: dc.typelivro digital-
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