Multilevel assessment of chlorothalonil sediment toxicity to Latin American estuarine biota: Effects on biomarkers, reproduction and survival in different benthic organisms

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Santa Cecília-
Autor(es): dc.contributorUniversidade Federal do Rio Grande (FURG)-
Autor(es): dc.creatorMorais, Lucas Gonçalves-
Autor(es): dc.creatorGusso-Choueri, Paloma Kachel-
Autor(es): dc.creatorAbreu, Fiamma Eugênia Lemos-
Autor(es): dc.creatorCastro, Ítalo Braga-
Autor(es): dc.creatorAbessa, Denis Moledo-
Autor(es): dc.creatorChoueri, Rodrigo Brasil-
Data de aceite: dc.date.accessioned2025-08-21T18:55:27Z-
Data de disponibilização: dc.date.available2025-08-21T18:55:27Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-05-10-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.scitotenv.2023.162215-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248377-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248377-
Descrição: dc.descriptionChlorothalonil is an organochlorine compound that has long been used in agriculture. In recent years, this compound has been used as an antifouling booster biocide and its presence has been reported in marine coastal environments, especially in navigational areas. Although sediment can be a sink for chlorothalonil due to high affinity to fine particulate matter, toxicity studies with non-target marine and/or estuarine organisms is focused on waterborne exposure only. This study aimed to determine sediment-borne ecotoxicological effects of chlorothalonil on different benthic organisms of the Latin American biota using a integrative multilevel approach. Marine/estuarine organisms were exposed to sediments spiked with chlorothalonil (from 0 to 10.0 μg g−1) and effects at sub-individual (biochemical biomarkers in Anomalocardia flexuosa), individual (lethal effects to Tiburonella viscana and Artemia salina) and subpopulation levels (Nitokra sp. reproduction) were assessed. Increasing chlorothalonil concentrations in sediment caused increasing ecotoxicological effects in different levels of biological organisation, from biochemical to subpopulation levels. The highest exposure concentrations showed increased biomarkers of effects (lipid peroxidation and DNA damage in gills and/or digestive gland of A. flexuosa), lower fecundity and lower survival of the test organisms. GPx activity associated with LPO levels in the digestive gland suggested a response to the oxidant challenge provided by the biocide. At the lowest concentration (0.001 μg g−1), chlorothalonil detoxification mechanisms and defense against its oxidising action, involving GSH and glutathione-dependent enzymes (GST and GPx) were induced. At intermediate concentrations, there was a tendency of decreasing GSH levels, probably due to conjugation with chlorothalonil, which also affected the activities of the glutathione-dependent enzymes. At the highest tested concentration (10.0 μg g−1), chlorothalonil may have restimulated GSH synthesis in the gills of A. flexuosa, although the prooxidant activity has induced effects. This study contributes to assessing the environmental risk of chlorothalonil in sediment for non-target marine and estuarine organisms.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFinanciadora de Estudos e Projetos-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartamento de Ciências do Mar Universidade Federal de São Paulo, Campus Baixada Santista, Rua Maria Máximo, 168, Ponta da Praia, Santos/SP-
Descrição: dc.descriptionCampus do Litoral Paulista Universidade Estadual Paulista Júlio de Mesquita Filho - Unesp, Praça Infante Dom Henrique, s/n, SP-
Descrição: dc.descriptionLaboratório de Ecotoxicologia - Unisanta Universidade Santa Cecília, R. Oswaldo Cruz, 277, Boqueirão, SP-
Descrição: dc.descriptionInstituto de Oceanografia Universidade Federal do Rio Grande (FURG), Av. Italia s/n, km 8, Campus Carreiros, RS-
Descrição: dc.descriptionCampus do Litoral Paulista Universidade Estadual Paulista Júlio de Mesquita Filho - Unesp, Praça Infante Dom Henrique, s/n, SP-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFinanciadora de Estudos e Projetos: 1111/13-
Descrição: dc.descriptionFAPESP: 2020/03004-0-
Descrição: dc.descriptionCNPq: 301766/2019-3-
Descrição: dc.descriptionCNPq: 304398/2021-7-
Descrição: dc.descriptionCNPq: 308533/2018-6),-
Descrição: dc.descriptionCNPq: 456372/2013-0-
Idioma: dc.languageen-
Relação: dc.relationScience of the Total Environment-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntifouling-
Palavras-chave: dc.subjectBiocide-
Palavras-chave: dc.subjectEcotoxicology-
Palavras-chave: dc.subjectGenotoxicity-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectPollution-
Título: dc.titleMultilevel assessment of chlorothalonil sediment toxicity to Latin American estuarine biota: Effects on biomarkers, reproduction and survival in different benthic organisms-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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