Electrochemical magneto-immunoassay for detection of zika virus antibody in human serum

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorButantan Institute-
Autor(es): dc.creatorCastro, Karla R.-
Autor(es): dc.creatorSetti, Grazielle O.-
Autor(es): dc.creatorde Oliveira, Tássia R.-
Autor(es): dc.creatorRodrigues-Jesus, Mônica J.-
Autor(es): dc.creatorBotosso, Viviane F.-
Autor(es): dc.creatorPerini de Araujo, Ana P.-
Autor(es): dc.creatorDurigon, Edson L.-
Autor(es): dc.creatorFerreira, Luis C.S.-
Autor(es): dc.creatorFaria, Ronaldo C.-
Data de aceite: dc.date.accessioned2025-08-21T16:38:41Z-
Data de disponibilização: dc.date.available2025-08-21T16:38:41Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.talanta.2023.124277-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248376-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248376-
Descrição: dc.descriptionZika virus (ZIKV) is a flavivirus transmitted by infected Aedes genus mosquitoes. An infected person may be asymptomatic or present symptoms such as fever, arthralgia, and in pregnancy it may lead to neurological disorders in the fetus, such as microcephaly. Based on the high dissemination potential of ZIVK and its similar antigen composition to other arboviruses, new approaches for selective virus detection are urgently needed. This work reports the development of an electrochemical immunoassay for detection of anti-ZIKV antibodies, using magnetic beads functionalized with recombinant protein derived from the non-structural protein 1 (ΔNS1-ZIKV) and anti-IgG antibodies labeled with horseradish peroxidase (HRP) enzyme. The magneto-immunoassay uses disposable microfluidic devices for detection of anti-ZIKV in serum samples. A linear response was obtained for a wide concentration range from 0.01 to 9.80 × 105 pg mL−1 (r2 = 0.982), with a limit of detection of 0.48 pg mL−1. The proposed immunoassay proved to be highly efficient for the detection of anti-ZIKV antibodies in serum, offering promising perspectives for the development of fast, simple, and affordable point-of-care diagnosis devices for ZIKV.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Chemistry Federal University of São Carlos, São Carlos-
Descrição: dc.descriptionDepartment of Physics School of Technology and Sciences São Paulo State University, Presidente Prudente-
Descrição: dc.descriptionInstitute of Biomedical Science University of São Paulo (ICB-USP)-
Descrição: dc.descriptionCenter for Development and Innovation Butantan Institute-
Descrição: dc.descriptionScientific Platform Pasteur/USP-
Descrição: dc.descriptionDepartment of Physics School of Technology and Sciences São Paulo State University, Presidente Prudente-
Descrição: dc.descriptionCNPq: 157272/2018-4-
Descrição: dc.descriptionFAPESP: 2014/22401-0-
Descrição: dc.descriptionFAPESP: 2016/20045-7-
Descrição: dc.descriptionFAPESP: 2018/04332-1-
Descrição: dc.descriptionCAPES: Finance Code 001-
Idioma: dc.languageen-
Relação: dc.relationTalanta-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDisposable microfluidic device-
Palavras-chave: dc.subjectElectrochemical immunoassay-
Palavras-chave: dc.subjectMagnetic beads-
Palavras-chave: dc.subjectZika virus infection-
Título: dc.titleElectrochemical magneto-immunoassay for detection of zika virus antibody in human serum-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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