Advances in the Molecular Landscape of Lung Cancer Brain Metastasis

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorBritish Columbia Cancer Research Institute-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorSouza, Vanessa G. P.-
Autor(es): dc.creatorde Araújo, Rachel Paes-
Autor(es): dc.creatorSantesso, Mariana R.-
Autor(es): dc.creatorSeneda, Ana Laura-
Autor(es): dc.creatorMinutentag, Iael W.-
Autor(es): dc.creatorFelix, Tainara Francini-
Autor(es): dc.creatorHamamoto Filho, Pedro Tadao-
Autor(es): dc.creatorPewarchuk, Michelle E.-
Autor(es): dc.creatorBrockley, Liam J.-
Autor(es): dc.creatorMarchi, Fábio A.-
Autor(es): dc.creatorLam, Wan L.-
Autor(es): dc.creatorDrigo, Sandra A.-
Autor(es): dc.creatorReis, Patricia P.-
Data de aceite: dc.date.accessioned2025-08-21T19:37:11Z-
Data de disponibilização: dc.date.available2025-08-21T19:37:11Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/cancers15030722-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248346-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248346-
Descrição: dc.descriptionLung cancer is one of the most frequent tumors that metastasize to the brain. Brain metastasis (BM) is common in advanced cases, being the major cause of patient morbidity and mortality. BMs are thought to arise via the seeding of circulating tumor cells into the brain microvasculature. In brain tissue, the interaction with immune cells promotes a microenvironment favorable to the growth of cancer cells. Despite multimodal treatments and advances in systemic therapies, lung cancer patients still have poor prognoses. Therefore, there is an urgent need to identify the molecular drivers of BM and clinically applicable biomarkers in order to improve disease outcomes and patient survival. The goal of this review is to summarize the current state of knowledge on the mechanisms of the metastatic spread of lung cancer to the brain and how the metastatic spread is influenced by the brain microenvironment, and to elucidate the molecular determinants of brain metastasis regarding the role of genomic and transcriptomic changes, including coding and non-coding RNAs. We also present an overview of the current therapeutics and novel treatment strategies for patients diagnosed with BM from NSCLC.-
Descrição: dc.descriptionMolecular Oncology Laboratory Experimental Research Unit Faculty of Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionBritish Columbia Cancer Research Institute-
Descrição: dc.descriptionDepartment of Neurology Psychology and Psychiatry Faculty of Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionFaculty of Medicine University of São Paulo-
Descrição: dc.descriptionDepartment of Surgery and Orthopedics Faculty of Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionMolecular Oncology Laboratory Experimental Research Unit Faculty of Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Neurology Psychology and Psychiatry Faculty of Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Surgery and Orthopedics Faculty of Medicine São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationCancers-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbrain metastasis-
Palavras-chave: dc.subjectcoding and non-coding RNAs-
Palavras-chave: dc.subjectlung cancer-
Palavras-chave: dc.subjectmicroenvironment-
Palavras-chave: dc.subjectmolecular mechanisms-
Palavras-chave: dc.subjecttherapeutic strategies-
Título: dc.titleAdvances in the Molecular Landscape of Lung Cancer Brain Metastasis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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