Embryo-fetal safety evaluation of ondansetron in rats

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Grande Dourados-
Autor(es): dc.creatorReis, Ana Carolina Casali-
Autor(es): dc.creatorJorge, Bárbara Campos-
Autor(es): dc.creatorda Silva Moreira, Suyane-
Autor(es): dc.creatorStein, Júlia-
Autor(es): dc.creatorPerdão, Carolina Barizan-
Autor(es): dc.creatorde Matos Manoel, Beatriz-
Autor(es): dc.creatorArena, Arielle Cristina-
Data de aceite: dc.date.accessioned2025-08-21T20:26:40Z-
Data de disponibilização: dc.date.available2025-08-21T20:26:40Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/bdr2.2154-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248319-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248319-
Descrição: dc.descriptionBackground: Ondansetron is a 5HT3 receptor antagonist, used to mitigate the effects of nausea and vomiting after chemotherapy or surgery. Since nausea and vomiting are common experiences during the first trimester of pregnancy, this antiemetic has been the main drug used during this period. Methods: To evaluate the effects of ondansetron on the embryo-fetal development, which are still very contradictory, pregnant rats were exposed to therapeutic doses of ondansetron (1.7 or 2.5 mg/kg) daily, from gestational day (GD) 6 to 15. Results: No clinical signs of toxicity were observed in dams during the treatment. Although the hemato-biochemical parameters were similar among the groups, histological changes, as well as a reduction in the weight of kidney were found in the treated dams. After fetal examination, no visceral and skeletal abnormalities were observed in treated fetuses. Conclusion: In conclusion, therapeutic doses of ondansetron have low teratogenic potential in rats. These data provide important information about the drug safety during pregnancy.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista – UNESP, São Paulo-
Descrição: dc.descriptionCollege of Health Science Federal University of Grande Dourados, Mato Grosso do Sul-
Descrição: dc.descriptionCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Universidade Estadual Paulista – Botucatu (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista – UNESP, São Paulo-
Descrição: dc.descriptionCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Universidade Estadual Paulista – Botucatu (UNESP), São Paulo-
Descrição: dc.descriptionFAPESP: 2020/08745-9-
Formato: dc.format605-613-
Idioma: dc.languageen-
Relação: dc.relationBirth Defects Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectkidney-
Palavras-chave: dc.subjectnausea and vomiting-
Palavras-chave: dc.subjectorganogenesis-
Palavras-chave: dc.subjectrats-
Palavras-chave: dc.subjectsafety-
Palavras-chave: dc.subjectteratogenicity-
Título: dc.titleEmbryo-fetal safety evaluation of ondansetron in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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