SARS-CoV-2 and Hypertension: Evidence Supporting Invasion into the Brain Via Baroreflex Circuitry and the Role of Imbalanced Renin-Angiotensin-Aldosterone-System

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Autor(es): dc.contributorFederal University of Alagoas (UFAL)-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorFederal University of Alagoas-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorTexas AM University School of Medicine-
Autor(es): dc.creatorOliveira, Kellysson Bruno-
Autor(es): dc.creatorMelo, Igor Santana de-
Autor(es): dc.creatorSilva, Bianca Rodrigues Melo da-
Autor(es): dc.creatorOliveira, Keylla Lavínia da Silva-
Autor(es): dc.creatorSabino-Silva, Robinson-
Autor(es): dc.creatorAnhezini, Lucas-
Autor(es): dc.creatorKatayama, Pedro Lourenco-
Autor(es): dc.creatorSantos, Victor Rodrigues-
Autor(es): dc.creatorShetty, Ashok K-
Autor(es): dc.creatorCastro, Olagide Wagner de-
Data de aceite: dc.date.accessioned2025-08-21T16:21:53Z-
Data de disponibilização: dc.date.available2025-08-21T16:21:53Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1177/26331055231151926-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248307-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248307-
Descrição: dc.descriptionHypertension is considered one of the most critical risk factors for COVID-19. Evidence suggests that SARS-CoV-2 infection produces intense effects on the cardiovascular system by weakening the wall of large vessels via vasa-vasorum. In this commentary, we propose that SARS-CoV-2 invades carotid and aortic baroreceptors, leading to infection of the nucleus tractus solitari (NTS) and paraventricular hypothalamic nucleus (PVN), and such dysregulation of NTS and PVN following infection causes blood pressure alteration at the central level. We additionally explored the hypothesis that SARS-CoV-2 favors the internalization of membrane ACE2 receptors generating an imbalance of the renin-angiotensin-aldosterone system (RAAS), increasing the activity of angiotensin II (ANG-II), disintegrin, and metalloproteinase 17 domain (ADAM17/TACE), eventually modulating the integration of afferents reaching the NTS from baroreceptors and promoting increased blood pressure. These mechanisms are related to the increased sympathetic activity, which leads to transient or permanent hypertension associated with SARS-CoV-2 invasion, contributing to the high number of deaths by cardiovascular implications.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Alagoas-
Descrição: dc.descriptionDepartment of Physiology Institute of Biological Sciences and Health Federal University of Alagoas (UFAL), Alagoas-
Descrição: dc.descriptionDepartment of Physiology Institute of Biomedical Sciences Federal University of Uberlandia (UFU), Minas Gerais-
Descrição: dc.descriptionDepartment of Histology Institute of Biological Sciences and Health Federal University of Alagoas, Alagoas-
Descrição: dc.descriptionDepartment of Physiology and Pathology Dentistry School of Araraquara São Paulo State University-
Descrição: dc.descriptionDepartment of Morphology Institute of Biological Science Federal University of Minas Gerais (UFMG), Minas Gerais-
Descrição: dc.descriptionInstitute for Regenerative Medicine Department of Cell Biology and Genetics Texas AM University School of Medicine-
Descrição: dc.descriptionDepartment of Physiology and Pathology Dentistry School of Araraquara São Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationNeuroscience Insights-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectangiotensin II-
Palavras-chave: dc.subjectbaroreflex-
Palavras-chave: dc.subjecthypertension-
Palavras-chave: dc.subjectSARS-CoV-2-
Título: dc.titleSARS-CoV-2 and Hypertension: Evidence Supporting Invasion into the Brain Via Baroreflex Circuitry and the Role of Imbalanced Renin-Angiotensin-Aldosterone-System-
Tipo de arquivo: dc.typetexto-
Aparece nas coleções:Repositório Institucional - Unesp

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