Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversity of Oulu-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Helsinki-
Autor(es): dc.contributorOswaldo Cruz Foundation-
Autor(es): dc.contributorUniversidade Federal da Bahia (UFBA)-
Autor(es): dc.contributorD’Or Institute for Research and Education (IDOR)-
Autor(es): dc.contributorFederal University of Alfenas-
Autor(es): dc.contributorUniversidad de los Andes-
Autor(es): dc.contributorMcGill University-
Autor(es): dc.contributorWestern Paranaí State University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDourado, Mauricio Rocha-
Autor(es): dc.creatorElseragy, Amr-
Autor(es): dc.creatorda Costa, Bruno Cesar-
Autor(es): dc.creatorTéo, Fábio Haach-
Autor(es): dc.creatorGuimarães, Gustavo Narvaes-
Autor(es): dc.creatorMachado, Renato Assis-
Autor(es): dc.creatorRisteli, Maija-
Autor(es): dc.creatorWahbi, Wafa-
Autor(es): dc.creatorGurgel Rocha, Clarissa Araujo-
Autor(es): dc.creatorParanaíba, Lívia Máris Ribeiro-
Autor(es): dc.creatorGonzález-Arriagada, Wilfredo Alejandro-
Autor(es): dc.creatorda Silva, Sabrina Daniela-
Autor(es): dc.creatorRangel, Ana Lucia Carrinho Ayroza-
Autor(es): dc.creatorMarques, Marcelo Rocha-
Autor(es): dc.creatorRossa Junior, Carlos-
Autor(es): dc.creatorSalo, Tuula-
Autor(es): dc.creatorColetta, Ricardo D.-
Data de aceite: dc.date.accessioned2025-08-21T16:44:31Z-
Data de disponibilização: dc.date.available2025-08-21T16:44:31Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-01-10-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fonc.2022.1085917-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248278-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248278-
Descrição: dc.descriptionObjective: Although there have been remarkable achievements in the molecular landscape of oral squamous cell carcinoma (OSCC) in recent years, bringing advances in the understanding of its pathogenesis, development and progression, little has been applied in the prognosis and choosing the optimal treatment. In this study, we explored the influence of the stress induced phosphoprotein 1 (STIP1), which is frequently reported to be highly expressed in many cancers, in OSCCs. Methods: STIP1 expression was assessed in the TCGA database and in two independent cohorts by immunohistochemistry. Knockdown strategy was applied in OSCC cell lines to determine the impact of STIP1 on viability, proliferation, migration and invasion. The zebrafish model was applied for studying tumor formation and metastasis in vivo. The association of STIP1 and miR-218-5p was explored by bioinformatics and mimics transfection. Results: STIP1 was highly expressed in OSCCs and significantly associated with shortened survival and higher risk of recurrence. STIP1 down-regulation decreased proliferation, migration and invasion of tumor cells, and reduced the number of metastases in the Zebrafish model. STIP1 and miR-218-5p were inversely expressed, and the transfection of miR-218-5p mimics into OSCC cells decreased STIP1 levels as well as proliferation, migration and invasion. Conclusion: Our findings show that STIP1 overexpression, which is inversely associated with miR-218-5p levels, contributes to OSCC aggressiveness by controlling proliferation, migration and invasion and is a determinant of poor prognosis.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Oral Diagnosis Graduate Program in Oral Biology Piracicaba Dental School University of Campinas, São Paulo-
Descrição: dc.descriptionCancer and Translational Medicine Research Unit Faculty of Medicine and Medical Research Center Oulu University Hospital University of Oulu-
Descrição: dc.descriptionDepartment of Biosciences and Graduate Program in Oral Biology Piracicaba Dental School University of Campinas, São Paulo-
Descrição: dc.descriptionHospital for Rehabilitation of Craniofacial Anomalies University of São Paulo (HRAC/USP), São Paulo-
Descrição: dc.descriptionDepartment of Oral and Maxillofacial Diseases Helsinki University Central Hospital Translational Immunology Research Program (TRIMM) University of Helsinki-
Descrição: dc.descriptionGonçalo Moniz Institute Oswaldo Cruz Foundation, Bahia-
Descrição: dc.descriptionFederal University of Bahia, Bahia-
Descrição: dc.descriptionCenter for Biotechnology and Cell Therapy D’Or Institute for Research and Education (IDOR)-
Descrição: dc.descriptionDepartment of Pathology and Parasitology Institute of Biomedical Sciences Federal University of Alfenas, Minas Gerais-
Descrição: dc.descriptionFacultad de Odontología Centro de Investigación e Innovación Biomédica (CIIB) Universidad de los Andes-
Descrição: dc.descriptionLady Davis Institute for Medical Research and Segal Cancer Center Jewish General Hospital and Department of Otolaryngology-Head and Neck Surgery McGill University-
Descrição: dc.descriptionDepartment of Oral Pathology and Oral Medicine Dental School Western Paranaí State University, Paraná-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry at Araraquara São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionHUSLAB Department of Pathology Helsinki University Central Hospital University of Helsinki-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry at Araraquara São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionCNPq: 407814/2018-3-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Oncology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectinvasion-
Palavras-chave: dc.subjectMIR-218-5p-
Palavras-chave: dc.subjectoral cancer-
Palavras-chave: dc.subjectprognosis-
Palavras-chave: dc.subjectproliferation-
Palavras-chave: dc.subjectSTIP1-
Título: dc.titleStress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.