Piperine Reduces Neoplastic Progression in Cervical Cancer Cells by Downregulating the Cyclooxygenase 2 Pathway

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorSchool of Medicine of Sao José do Rio Preto (FAMERP)-
Autor(es): dc.creatorCardoso, Luana Pereira-
Autor(es): dc.creatorde Sousa, Stefanie Oliveira-
Autor(es): dc.creatorGusson-Zanetoni, Juliana Prado-
Autor(es): dc.creatorde Melo Moreira Silva, Laura Luciana-
Autor(es): dc.creatorFrigieri, Barbara Maria-
Autor(es): dc.creatorHenrique, Tiago-
Autor(es): dc.creatorTajara, Eloiza Helena-
Autor(es): dc.creatorOliani, Sonia Maria-
Autor(es): dc.creatorRodrigues-Lisoni, Flávia Cristina-
Data de aceite: dc.date.accessioned2025-08-21T21:27:02Z-
Data de disponibilização: dc.date.available2025-08-21T21:27:02Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ph16010103-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248259-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248259-
Descrição: dc.descriptionCervical cancer is the fourth-most common type of cancer in the world that causes death in women. It is mainly caused by persistent infection by human papillomavirus (HPV) that triggers a chronic inflammatory process. Therefore, the use of anti-inflammatory drugs is a potential treatment option. The effects of piperine, an amino alkaloid derived from Piper nigrum, are poorly understood in cervical cancer inflammation, making it a target of research. This work aimed to investigate the antitumor effect of piperine on cervical cancer and to determine whether this effect is modulated by the cyclooxygenase 2 (PTGS2) pathway using in vitro model of cervical cancer (HeLa, SiHa, CaSki), and non-tumoral (HaCaT) cell lines. The results showed that piperine reduces in vitro parameters associated with neoplastic evolution such as proliferation, viability and migration by cell cycle arrest in the G1/G0 and G2/M phases, with subsequent induction of apoptosis. This action was modulated by downregulation of cyclooxygenase 2 (PTGS2) pathway, which in turn regulates the secretion of cytokines and the expression of mitogen-activated protein kinases (MAPKs), metalloproteinases (MMPs), and their antagonists (TIMPs). These findings indicate the phytotherapeutic potential of piperine as complementary treatment in cervical cancer.-
Descrição: dc.descriptionSão Paulo State University (Unesp) Institute of Biosciences Humanities and Exact Sciences (IBILCE) Department of Biology Science-
Descrição: dc.descriptionDepartment of Molecular Biology School of Medicine of Sao José do Rio Preto (FAMERP)-
Descrição: dc.descriptionSão Paulo State University (Unesp) School of Natural Sciences and Engineering-
Descrição: dc.descriptionSão Paulo State University (Unesp) Institute of Biosciences Humanities and Exact Sciences (IBILCE) Department of Biology Science-
Descrição: dc.descriptionSão Paulo State University (Unesp) School of Natural Sciences and Engineering-
Idioma: dc.languageen-
Relação: dc.relationPharmaceuticals-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectalkaloid-
Palavras-chave: dc.subjectgynecological cancer-
Palavras-chave: dc.subjectherbal medicines-
Palavras-chave: dc.subjectpiperine-
Título: dc.titlePiperine Reduces Neoplastic Progression in Cervical Cancer Cells by Downregulating the Cyclooxygenase 2 Pathway-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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