Presentation, medical complications and development of gestational trophoblastic neoplasia of hydatidiform mole after intracytoplasmic sperm injection as compared to hydatidiform mole after spontaneous conception - a retrospective cohort study and literature review

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorMaternity School of Rio de Janeiro Federal University-
Autor(es): dc.contributorFluminense Federal University-
Autor(es): dc.contributorVassouras University-
Autor(es): dc.contributorYoung Leadership Physicians Program-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorHospital Moinhos de Vento-
Autor(es): dc.contributorHarvard Medical School-
Autor(es): dc.creatorBraga, Antonio-
Autor(es): dc.creatorAndrade, Taiane-
Autor(es): dc.creatordo Carmo Borges de Souza, Maria-
Autor(es): dc.creatorCampos, Vanessa-
Autor(es): dc.creatorFreitas, Fernanda-
Autor(es): dc.creatorMaestá, Izildinha-
Autor(es): dc.creatorSun, Sue Yazaki-
Autor(es): dc.creatorPedrotti, Luana Giongo-
Autor(es): dc.creatorBessel, Marina-
Autor(es): dc.creatorJunior, Joffre Amim-
Autor(es): dc.creatorFilho, Jorge Rezende-
Autor(es): dc.creatorElias, Kevin M.-
Autor(es): dc.creatorHorowitz, Neil S.-
Autor(es): dc.creatorBerkowitz, Ross S.-
Data de aceite: dc.date.accessioned2025-08-21T18:17:47Z-
Data de disponibilização: dc.date.available2025-08-21T18:17:47Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ygyno.2023.01.016-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248248-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248248-
Descrição: dc.descriptionObjective: To describe the natural history of hydatidiform mole (HM) after intracytoplasmic sperm injection (ICSI), emphasizing the clinical and oncological outcomes, as compared to patients who had HM after spontaneous conception (SC). Study design: Retrospective historical cohort study of patients with HM followed at the Rio de Janeiro Federal University, from January 1st 2000-December 31st 2020. Results: Comparing singleton HM after SC to those following ICSI there were differences in terms of maternal age (24 vs 34 years, p < 0.01), gestational age at diagnosis (10 vs 7 weeks, p < 0.01), preevacuation human chorionic gonadotropin levels (200,000 vs 99,000 IU/L, p < 0.01), occurrence of genital bleeding (60.5 vs 26.9%, p < 0.01) and hyperemesis (23 vs 3.9%, p = 0.02) at presentation, and time to remission (12 vs 5 weeks, p < 0.01), respectively. There were no differences observed in the cases of twin mole, regardless of the form of fertilization that gave rise to HM, except molar histology with greater occurrence of partial hydatidiform mole (10.7 vs 40.0%, p = 0.01) following ICSI. Univariate logistic regression for occurrence of postmolar GTN after ICSI identified no predictor variable for this outcome. However, after adjusting for maternal age and complete hydatidiform mole histology, multivariable logistic regression showed the risk of GTN with HM after ICSI had an adjusted odds ratio of 0.22 (95%CI:0.05–0.93, p = 0.04), suggesting a possible protective effect when compared to HM after SC. Conclusions: Singleton HM after ICSI are diagnosed earlier in gestation, present with fewer medical complications, and may be less likely to develop GTN when compared with HM after SC.-
Descrição: dc.descriptionRio de Janeiro Trophoblastic Disease Center (Maternity School of Rio de Janeiro Federal University Antonio Pedro University Hospital of Fluminense Federal University) Postgraduate Program in Perinatal Health Faculty of Medicine Maternity School of Rio de Janeiro Federal University, RJ-
Descrição: dc.descriptionPostgraduate Program in Medical Sciences Fluminense Federal University, RJ-
Descrição: dc.descriptionPostgraduate Program in Applied Health Sciences Vassouras University, RJ-
Descrição: dc.descriptionNational Academy of Medicine Young Leadership Physicians Program, RJ-
Descrição: dc.descriptionBotucatu Trophoblastic Disease Center of the Clinical Hospital of Botucatu Medical School Department of Gynecology and Obstetrics São Paulo State University - UNESP, SP-
Descrição: dc.descriptionDepartament of Obstetrics Escola Paulista de Medicina Universidade Federal de São Paulo, SP-
Descrição: dc.descriptionHospital Moinhos de Vento, RS-
Descrição: dc.descriptionNew England Trophoblastic Disease Center Division of Gynecologic Oncology Department of Obstetrics Gynecology and Reproductive Biology Brigham and Women's Hospital Dana Farber Cancer Institute Harvard Medical School-
Descrição: dc.descriptionBotucatu Trophoblastic Disease Center of the Clinical Hospital of Botucatu Medical School Department of Gynecology and Obstetrics São Paulo State University - UNESP, SP-
Formato: dc.format179-185-
Idioma: dc.languageen-
Relação: dc.relationGynecologic Oncology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAssisted reproductive techniques-
Palavras-chave: dc.subjectGestational trophoblastic disease-
Palavras-chave: dc.subjectGestational trophoblastic neoplasia-
Palavras-chave: dc.subjectHuman chorionic gonadotropin-
Palavras-chave: dc.subjectHydatidiform mole-
Palavras-chave: dc.subjectIntracytoplasmic sperm injection-
Título: dc.titlePresentation, medical complications and development of gestational trophoblastic neoplasia of hydatidiform mole after intracytoplasmic sperm injection as compared to hydatidiform mole after spontaneous conception - a retrospective cohort study and literature review-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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