Development of multiparticulate systems based on natural polymers for morin controlled release

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Araraquara - UNIARA-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorSales, Luciana Solera-
Autor(es): dc.creatorGimenes, Milena da Silva-
Autor(es): dc.creatorMeneguin, Andréia Bagliotti-
Autor(es): dc.creatorBarud, Hernane da Silva-
Autor(es): dc.creatorAchcar, Jorge Alberto-
Autor(es): dc.creatorBrighenti, Fernanda Lourenção-
Data de aceite: dc.date.accessioned2025-08-21T20:17:37Z-
Data de disponibilização: dc.date.available2025-08-21T20:17:37Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-02-14-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2022.12.146-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248185-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248185-
Descrição: dc.descriptionThis study aimed to develop a multiparticulate system based on sodium alginate/gellan gum polymers for morin controlled release using standardized spray-dryer parameters. A 24 experimental factorial design was used to standardize spray-dryer parameters. After standardization, three systems with three different proportions of the natural polymers (50:50, 25:75, 75:25; sodium alginate: gellan gum) with and without morin (control) were developed. The systems were characterized according to its morphology and physicochemical properties. Next, the systems were evaluated regarding antibiofilm and antimicrobial activity against Streptococcus mutans. The factorial design indicated the use of the following parameters: i) air flow rate: 1.0 m3 /min; ii) outlet temperature: 120 °C; iii) natural polymers combination in different proportions; iiii) polymer concentration: 2 %. Scanning electron microscopy showed microparticles with spherical shape and rough surface. The samples released 99.86 % ± 9.36; 85.45 % ± 8.31; 86.87 % ± 3.83 of morin after 480 min. The systems containing morin significantly reduced S. mutans biofilm biomass, microbial viability and acidogenicity when compared to their respective controls. In conclusion, the spray-dryer parameters were standardized to the highest possible yield values and proved to be efficient for morin encapsulation and controlled release. Furthermore, these systems controlled important virulence factors of S. mutans biofilms.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Morphology Genetics Orthodontics and Pediatric Dentistry São Paulo State University (Unesp) School of Dentistry, R. Humaitá, 1680 – Centro, São Paulo-
Descrição: dc.descriptionDepartment of Drugs and Pharmaceuticals São Paulo State University (Unesp) School of Pharmaceutical Sciences, Jaú, Km 1, CP 502, São Paulo-
Descrição: dc.descriptionBiopolymers and Biomaterials Laboratory (BioPolMat) University of Araraquara - UNIARA, SP-
Descrição: dc.descriptionMedical School University of São Paulo, SP-
Descrição: dc.descriptionDepartment of Morphology Genetics Orthodontics and Pediatric Dentistry São Paulo State University (Unesp) School of Dentistry, R. Humaitá, 1680 – Centro, São Paulo-
Descrição: dc.descriptionDepartment of Drugs and Pharmaceuticals São Paulo State University (Unesp) School of Pharmaceutical Sciences, Jaú, Km 1, CP 502, São Paulo-
Descrição: dc.descriptionFAPESP: 2013/07276-1-
Descrição: dc.descriptionFAPESP: 2017/50334-3-
Descrição: dc.descriptionFAPESP: 2018/25512-8-
Descrição: dc.descriptionFAPESP: 2019/08375-0-
Descrição: dc.descriptionFAPESP: 2019/19817-3-
Descrição: dc.descriptionFAPESP: 2019/26066-4-
Descrição: dc.descriptionFAPESP: 2021/12931-5-
Descrição: dc.descriptionCNPq: 313473/2019-6-
Descrição: dc.descriptionCNPq: 407822/2018-6-
Formato: dc.format1-12-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Biological Macromolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiofilm-
Palavras-chave: dc.subjectGellan gum-
Palavras-chave: dc.subjectMorin hydrate-
Palavras-chave: dc.subjectSodium alginate-
Título: dc.titleDevelopment of multiparticulate systems based on natural polymers for morin controlled release-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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