Tissue Bioengineering with Fibrin Scaffolds and Deproteinized Bone Matrix Associated or Not with the Transoperative Laser Photobiomodulation Protocol

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Marilia (UNIMAR)-
Autor(es): dc.contributorUniversity Center of Adamantina (UNIFAI)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUNINOVE University-
Autor(es): dc.creatorPomini, Karina Torres-
Autor(es): dc.creatorBuchaim, Daniela Vieira-
Autor(es): dc.creatorBighetti, Ana Carolina Cestari-
Autor(es): dc.creatorHamzé, Abdul Latif-
Autor(es): dc.creatorReis, Carlos Henrique Bertoni-
Autor(es): dc.creatorDuarte, Marco Antonio Húngaro-
Autor(es): dc.creatorAlcalde, Murilo Priori-
Autor(es): dc.creatorBarraviera, Benedito-
Autor(es): dc.creatorJúnior, Rui Seabra Ferreira-
Autor(es): dc.creatorde Souza, Alexandre Teixeira-
Autor(es): dc.creatorda Silva Santos, Paulo Sérgio-
Autor(es): dc.creatorPilon, João Paulo Galletti-
Autor(es): dc.creatorde Marchi, Miguel Ângelo-
Autor(es): dc.creatorNogueira, Dayane Maria Braz-
Autor(es): dc.creatorde Souza Bueno, Cleuber Rodrigo-
Autor(es): dc.creatorSoares, Wendel Cleber-
Autor(es): dc.creatorBuchaim, Rogerio Leone-
Data de aceite: dc.date.accessioned2025-08-21T20:12:30Z-
Data de disponibilização: dc.date.available2025-08-21T20:12:30Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/molecules28010407-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248148-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248148-
Descrição: dc.descriptionExtending the range of use of the heterologous fibrin biopolymer, this pre-clinical study showed a new proportionality of its components directed to the formation of scaffold with a lower density of the resulting mesh to facilitate the infiltration of bone cells, and combined with therapy by laser photobiomodulation, in order to accelerate the repair process and decrease the morphofunctional recovery time. Thus, a transoperative protocol of laser photobiomodulation (L) was evaluated in critical bone defects filled with deproteinized bovine bone particles (P) associated with heterologous fibrin biopolymer (HF). The groups were: BCL (blood clot + laser); HF; HFL; PHF (P+HF); PHFL (P+HF+L). Microtomographically, bone volume (BV) at 14 days, was higher in the PHF and PHFL groups (10.45 ± 3.31 mm3 and 9.94 ± 1.51 mm3), significantly increasing in the BCL, HFL and PHFL groups. Histologically, in all experimental groups, the defects were not reestablished either in the external cortical bone or in the epidural, occurring only in partial bone repair. At 42 days, the bone area (BA) increased in all groups, being significantly higher in the laser-treated groups. The quantification of bone collagen fibers showed that the percentage of collagen fibers in the bone tissue was similar between the groups for each experimental period, but significantly higher at 42 days (35.71 ± 6.89%) compared to 14 days (18.94 ± 6.86%). It can be concluded that the results of the present study denote potential effects of laser radiation capable of inducing functional bone regeneration, through the synergistic combination of biomaterials and the new ratio of heterologous fibrin biopolymer components (1:1:1) was able to make the resulting fibrin mesh less dense and susceptible to cellular permeability. Thus, the best fibrinogen concentration should be evaluated to find the ideal heterologous fibrin scaffold.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru School of Dentistry (FOB/USP) University of São Paulo-
Descrição: dc.descriptionPostgraduate Program in Structural and Functional Interactions in Rehabilitation Postgraduate Department University of Marilia (UNIMAR)-
Descrição: dc.descriptionTeaching and Research Coordination of the Medical School University Center of Adamantina (UNIFAI)-
Descrição: dc.descriptionMedical School University of Marilia (UNIMAR)-
Descrição: dc.descriptionUNIMAR Beneficent Hospital (HBU) University of Marilia (UNIMAR)-
Descrição: dc.descriptionDepartment of Dentistry Endodontics and Dental Materials Bauru School of Dentistry University of São Paulo (FOB/USP)-
Descrição: dc.descriptionCenter for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (University Estadual Paulista UNESP)-
Descrição: dc.descriptionGraduate Programs in Tropical Diseases and Clinical Research Botucatu Medical School (FMB) São Paulo State University (UNESP–University Estadual Paulista)-
Descrição: dc.descriptionUniversity Center of Adamantina (UNIFAI)-
Descrição: dc.descriptionDepartment of Surgery Stomatology Pathology and Radiology Bauru School of Dentistry University of São Paulo-
Descrição: dc.descriptionPostgraduate Program in Speech Therapy São Paulo State University (UNESP—University Estadual Paulista)-
Descrição: dc.descriptionCoordination of the Medical School University Center of Adamantina (UNIFAI)-
Descrição: dc.descriptionDepartment of Prosthodontics and Periodontics Bauru School of Dentistry (FOB/USP) University of São Paulo-
Descrição: dc.descriptionAnatomy and Collective Health Faculty of Medicine and Dentistry University Center of Adamantina (UNIFAI)-
Descrição: dc.descriptionAnatomy Department Faculty of Medicine UNINOVE University-
Descrição: dc.descriptionGraduate Program in Anatomy of Domestic and Wild Animals Faculty of Veterinary Medicine and Animal Science University of São Paulo (FMVZ/USP)-
Descrição: dc.descriptionCenter for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (University Estadual Paulista UNESP)-
Descrição: dc.descriptionGraduate Programs in Tropical Diseases and Clinical Research Botucatu Medical School (FMB) São Paulo State University (UNESP–University Estadual Paulista)-
Descrição: dc.descriptionPostgraduate Program in Speech Therapy São Paulo State University (UNESP—University Estadual Paulista)-
Descrição: dc.descriptionCNPq: 303224/2018-5-
Descrição: dc.descriptionCNPq: 306339/2020-0-
Idioma: dc.languageen-
Relação: dc.relationMolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbiocompatible materials-
Palavras-chave: dc.subjectbiopolymers-
Palavras-chave: dc.subjectbone regeneration-
Palavras-chave: dc.subjectbone substitutes-
Palavras-chave: dc.subjectfibrin sealant-
Palavras-chave: dc.subjectlow-level laser therapy-
Palavras-chave: dc.subjectphotobiomodulation-
Palavras-chave: dc.subjectxenografts-
Título: dc.titleTissue Bioengineering with Fibrin Scaffolds and Deproteinized Bone Matrix Associated or Not with the Transoperative Laser Photobiomodulation Protocol-
Tipo de arquivo: dc.typelivro digital-
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