Acute and chronic effects of the organophosphate malathion on the pancreatic α and β cell viability, cell structure, and voltage-gated K+ currents.

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal de Santa Catarina (UFSC)-
Autor(es): dc.contributorUniversity of Alicante-
Autor(es): dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidad Miguel Hernández-
Autor(es): dc.contributorBiomedical Research Center in Diabetes and Associated Metabolic Disorders (CIBERDEM)-
Autor(es): dc.creatorMartins, J.R.N-
Autor(es): dc.creatorLopes, S.-
Autor(es): dc.creatorHurtado, H. N.-
Autor(es): dc.creatorda Silva, F. N.-
Autor(es): dc.creatorVillard, D. R.-
Autor(es): dc.creatorTaboga, S. R.-
Autor(es): dc.creatorSouza, K.L.A-
Autor(es): dc.creatorQuesada, I.-
Autor(es): dc.creatorSoriano, S.-
Autor(es): dc.creatorRafacho, A.-
Data de aceite: dc.date.accessioned2025-08-21T20:09:56Z-
Data de disponibilização: dc.date.available2025-08-21T20:09:56Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.etap.2022.104046-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248117-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248117-
Descrição: dc.descriptionStudies indicate that the pesticide malathion may have a role in diabetes. Herein, we determined the effects of different concentrations of malathion on survival, ultrastructure, and electrophysiologic islet cell parameters. Acutely, high concentrations of malathion (0.5 or 1 mM) increased cell death in rat islet cells, while low concentrations (0.1 mM) caused signs of cell damage in pancreatic α and β cells. Exposure of RINm5F cells to malathion for 24 or 48 h confirmed the reduction in β-cell viability at lower concentrations (0.001–100 µM). Chronic exposure of mouse pancreatic α and β cells to 3 nM of malathion led to increased voltage-gated K+ (Kv) currents in α-cells. Our findings show a time and concentration dependency for the malathion effect on the reduction of islet cell viability and indicate that pancreatic α cells are more sensitive to malathion effects on Kv currents and cell death.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionGeneralitat Valenciana-
Descrição: dc.descriptionLaboratory of Investigation in Chronic Diseases LIDoC Department of Physiological Sciences Center of Biological Sciences Federal University of Santa Catarina UFSC-
Descrição: dc.descriptionGraduate Program in Pharmacology Center of Biological Sciences Federal University of Santa Catarina UFSC-
Descrição: dc.descriptionCentral Laboratory of Electron Microscopy LCME PROPESQ Federal University of Santa Catarina UFSC-
Descrição: dc.descriptionDepartment of Physiology Genetics and Microbiology University of Alicante-
Descrição: dc.descriptionNUMPEX-BIO Campus Duque de Caxias Universidade Federal do Rio de Janeiro (UFRJ) Campus UFRJ Duque de Caxias Prof. Geraldo Cidade-
Descrição: dc.descriptionDepartment of Biological Sciences Laboratory of Microscopy and Microanalysis Universidade Estadual Paulista-UNESP-
Descrição: dc.descriptionInstituto de Investigación Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE) Universidad Miguel Hernández-
Descrição: dc.descriptionBiomedical Research Center in Diabetes and Associated Metabolic Disorders (CIBERDEM)-
Descrição: dc.descriptionDepartment of Biological Sciences Laboratory of Microscopy and Microanalysis Universidade Estadual Paulista-UNESP-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionCNPq: 304338/2020–3-
Descrição: dc.descriptionGeneralitat Valenciana: PROMETEO/2020/006-
Idioma: dc.languageen-
Relação: dc.relationEnvironmental Toxicology and Pharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEndocrine disrupting chemicals-
Palavras-chave: dc.subjectEnvironmental contaminants-
Palavras-chave: dc.subjectHealth concerns-
Palavras-chave: dc.subjectIslets of Langerhans-
Palavras-chave: dc.subjectMorphology-
Título: dc.titleAcute and chronic effects of the organophosphate malathion on the pancreatic α and β cell viability, cell structure, and voltage-gated K+ currents.-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.