Chitosan and HPMCAS double-coating as protective systems for alginate microparticles loaded with Ctx(Ile21)-Ha antimicrobial peptide to prevent intestinal infections

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidad de Talca-
Autor(es): dc.creatorRoque-Borda, Cesar Augusto-
Autor(es): dc.creatorSaraiva, Mauro de Mesquita Souza-
Autor(es): dc.creatorMacedo Junior, Wagner Dias-
Autor(es): dc.creatorMárquez Montesinos, José Carlos Estanislao-
Autor(es): dc.creatorMeneguin, Andréia Bagliotti-
Autor(es): dc.creatorToledo Borges, Anna Beatriz-
Autor(es): dc.creatorCrusca Junior, Edson-
Autor(es): dc.creatorGarrido, Saulo Santesso-
Autor(es): dc.creatorde Almeida, Adriana Maria-
Autor(es): dc.creatorMarchetto, Reinaldo-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorBerchieri Junior, Angelo-
Autor(es): dc.creatorTeixeira, Silvio Rainho-
Autor(es): dc.creatorPavan, Fernando Rogério-
Autor(es): dc.creatorVicente, Eduardo Festozo-
Data de aceite: dc.date.accessioned2025-08-21T18:10:39Z-
Data de disponibilização: dc.date.available2025-08-21T18:10:39Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.biomaterials.2022.121978-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248114-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248114-
Descrição: dc.descriptionThe incorrect use of conventional drugs for both prevention and control of intestinal infections has contributed to a significant spread of bacterial resistance. In this way, studies that promote their replacement are a priority. In the last decade, the use of antimicrobial peptides (AMP), especially Ctx(Ile21)-Ha AMP, has gained strength, demonstrating efficient antimicrobial activity (AA) against pathogens, including multidrug-resistant bacteria. However, gastrointestinal degradation does not allow its direct oral application. In this research, double-coating systems using alginate microparticles loaded with Ctx(Ile21)-Ha peptide were designed, and in vitro release assays simulating the gastrointestinal tract were evaluated. Also, the AA against Salmonella spp. and Escherichia coli was examined. The results showed the physicochemical stability of Ctx(Ile21)-Ha peptide in the system and its potent antimicrobial activity. In addition, the combination of HPMCAS and chitosan as a gastric protection system can be promising for peptide carriers or other low pH-sensitive molecules, adequately released in the intestine. In conclusion, the coated systems employed in this study can improve the formulation of new foods or biopharmaceutical products for specific application against intestinal pathogens in animal production or, possibly, in the near future, in human health.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSão Paulo State University (Unesp) School of Pharmaceutical Sciences, Araraquara-
Descrição: dc.descriptionSão Paulo State University (Unesp) School of Agricultural and Veterinarian Sciences, Jaboticabal-
Descrição: dc.descriptionSão Paulo State University (Unesp) School of Technology and Sciences, Presidente Prudente-
Descrição: dc.descriptionCentro de Bioinformática Simulación y Modelado (CBSM) Universidad de Talca-
Descrição: dc.descriptionSão Paulo State University (Unesp) Institute of Chemistry, Araraquara-
Descrição: dc.descriptionSão Paulo State University (Unesp) School of Sciences and Engineering, Tupã-
Descrição: dc.descriptionSão Paulo State University (Unesp) School of Pharmaceutical Sciences, Araraquara-
Descrição: dc.descriptionSão Paulo State University (Unesp) School of Agricultural and Veterinarian Sciences, Jaboticabal-
Descrição: dc.descriptionSão Paulo State University (Unesp) School of Technology and Sciences, Presidente Prudente-
Descrição: dc.descriptionSão Paulo State University (Unesp) Institute of Chemistry, Araraquara-
Descrição: dc.descriptionSão Paulo State University (Unesp) School of Sciences and Engineering, Tupã-
Descrição: dc.descriptionFAPESP: 2016/00446–7-
Descrição: dc.descriptionFAPESP: 2018/25707–3-
Descrição: dc.descriptionFAPESP: 2020/16573–3-
Idioma: dc.languageen-
Relação: dc.relationBiomaterials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAMP-
Palavras-chave: dc.subjectChitosan-
Palavras-chave: dc.subjectEnteric coating-
Palavras-chave: dc.subjectHPMCAS-
Palavras-chave: dc.subjectIn vitro release-
Palavras-chave: dc.subjectMicroparticles-
Título: dc.titleChitosan and HPMCAS double-coating as protective systems for alginate microparticles loaded with Ctx(Ile21)-Ha antimicrobial peptide to prevent intestinal infections-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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