Acute kidney injury in coronavirus infectious disease: a study of incidence, risk factors, and prognosis during the first wave of the disease in Brazil

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMagalhães, Luís Eduardo-
Autor(es): dc.creatorde Oliveira, Paula Gabriela Sousa-
Autor(es): dc.creatorFavarin, Ana Júlia-
Autor(es): dc.creatorYuasa, Bruna Kaori-
Autor(es): dc.creatorCardoso, Pedro Andriolo-
Autor(es): dc.creatorZamoner, Welder-
Autor(es): dc.creatorPonce, Daniela-
Data de aceite: dc.date.accessioned2025-08-21T15:28:49Z-
Data de disponibilização: dc.date.available2025-08-21T15:28:49Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11255-022-03454-4-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248106-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248106-
Descrição: dc.descriptionIntroduction: Acute kidney injury (AKI) is one of the main complications of COVID-19 caused by SARS-CoV-2. This study aimed to evaluate the incidence of AKI in Brazilian hospitalized patients diagnosed with COVID-19 and identify the risk factors associated with its onset and those associated with its prognosis. Methods: A prospective cohort study of hospitalized patients diagnosed with COVID-19 at a public and tertiary university hospital in São Paulo from March to December 2020. Results: There were 347 patients hospitalized with COVID-19, 52.4% were admitted to the intensive care unit (ICU) and 47.6% were admitted to the wards. The overall incidence of AKI was 46.4%, more frequent in the ICU (68.1% vs 22.4, p < 0.01) and the overall mortality was 36.1%. Acute kidney replacement therapy was indicated in 46.6% of patients with AKI. In the general population, the factors associated with AKI were older age (OR 1.03, CI 1–1.05, p < 0.05), mechanical ventilation (OR 1.23, CI 1.06–1.83, p < 0.05), presence of proteinuria (OR 1.46, CI 1.22–1.93, p < 0.05), and use of vasoactive drugs (OR 1.26, CI 1.07–1.92, p < 0.05). Mortality was higher in the elderly (OR 1.08, CI 1.04–1.11, p < 0.05), in those with AKI (OR 1.12, CI 1.02–2.05, p < 0.05), particularly KDIGO stage 3 AKI (OR 1.10, CI 1.22–2.05, p < 0.05) and in need of mechanical ventilation (OR 1.13, CI 1.03–1.60, p < 0.05). Conclusion: AKI was frequent in hospitalized patients with COVID-19 and the factors associated with its development were older age, mechanical ventilation, use of vasoactive drugs, and presence of proteinuria, being a risk factor for death.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSchool of Medicine Faculdade de Medicina de Botucatu-UNESP, SP-
Descrição: dc.descriptionDepartamento de Clínica Médica Faculdade de Medicina de Botucatu-UNESP, SP-
Descrição: dc.descriptionSchool of Medicine Faculdade de Medicina de Botucatu-UNESP, SP-
Descrição: dc.descriptionDepartamento de Clínica Médica Faculdade de Medicina de Botucatu-UNESP, SP-
Descrição: dc.descriptionFAPESP: 2020/117668-
Formato: dc.format1501-1508-
Idioma: dc.languageen-
Relação: dc.relationInternational Urology and Nephrology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAKI-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectCross-talk-
Palavras-chave: dc.subjectIncidence-
Palavras-chave: dc.subjectMortality-
Título: dc.titleAcute kidney injury in coronavirus infectious disease: a study of incidence, risk factors, and prognosis during the first wave of the disease in Brazil-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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