Efficacy and Safety of Topical or Oral Hydrolyzed Collagen in Women with Dermatoporosis: A Randomized, Double-Blind, Factorial Design Study

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Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorDuke University Medical Center-
Autor(es): dc.creatorGuadanhim, Lilia R. S.-
Autor(es): dc.creatorMiot, Hélio A.-
Autor(es): dc.creatorSoares, Juliana L. M.-
Autor(es): dc.creatorSilva, Silas A. M.-
Autor(es): dc.creatorLeonardi, Gislaine R.-
Autor(es): dc.creatorLopes, Renato D.-
Autor(es): dc.creatorBagatin, Ediléia-
Data de aceite: dc.date.accessioned2025-08-21T21:38:38Z-
Data de disponibilização: dc.date.available2025-08-21T21:38:38Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s13555-022-00859-y-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248079-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248079-
Descrição: dc.descriptionBackground: Dermatoporosis defines the progressive chronic cutaneous insufficiency syndrome. Stage I is characterized by cutaneous atrophy, senile purpura, and stellate pseudoscars. Objective: To assess clinical, histologic, quality of life, and biophysical effects of oral and/or topical hydrolyzed collagen (HC) on forearm skin of postmenopausal women with Dermatoporosis stage I. Methods: Double-blind randomized placebo-controlled factorial design study. Two groups of menopausal women with stage I dermatoporosis on forearms were randomized to oral HC 5 g/day or matching placebo, and also to topical serum 2.5% HC or matching placebo once a day, for 6 months. Results: A total of 56 women, age range 60–93 years (mean 69.5 ± 7.3 years) were included. Comparing data from baseline and after 6 months, no significant difference was observed for each intervention nor their comparison, for all efficacy parameters: clinical and quality of life scores, dermal elasticity, thickness and echogenicity, and histologic and immunohistochemical markers (p > 0.1). Limitations: Larger studies to confirm our findings are warranted. Conclusions: In menopausal women with stage I dermatoporosis, oral or topical collagen peptides used alone or in combination do not have benefits on forearm skin after 6 months of intervention, and therefore should not be used routinely in this population. Graphical Abstract: CONSORT flow chart [Figure not available: see fulltext.].-
Descrição: dc.descriptionUniversidade Federal de São Paulo-
Descrição: dc.descriptionDepartment of Dermatology Universidade Federal de São Paulo/UNIFESP, Rua Botucatu, 821 - 5o andar-
Descrição: dc.descriptionDepartment of Dermatology Universidade Estadual de São Paulo/UNESP-
Descrição: dc.descriptionFaculty of Pharmaceutical Sciences Universidade Estadual de Campinas/UNICAMP-
Descrição: dc.descriptionDivision of Cardiology Duke University Medical Center-
Descrição: dc.descriptionDepartment of Dermatology Universidade Estadual de São Paulo/UNESP-
Formato: dc.format523-534-
Idioma: dc.languageen-
Relação: dc.relationDermatology and Therapy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCollagen peptides-
Palavras-chave: dc.subjectCutaneous atrophy-
Palavras-chave: dc.subjectDermatoporosis-
Palavras-chave: dc.subjectHydrolyzed collagen-
Palavras-chave: dc.subjectPhotoaging-
Palavras-chave: dc.subjectSenile purpura-
Título: dc.titleEfficacy and Safety of Topical or Oral Hydrolyzed Collagen in Women with Dermatoporosis: A Randomized, Double-Blind, Factorial Design Study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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