Safety evaluation of ondansetron after gestational exposure on male reproductive parameters in rats

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Grande Dourados (UFGD)-
Autor(es): dc.creatorReis, Ana Carolina Casali-
Autor(es): dc.creatorJorge, Bárbara Campos-
Autor(es): dc.creatorStein, Julia-
Autor(es): dc.creatorMoreira, Suyane da Silva-
Autor(es): dc.creatorManoel, Beatriz de Matos-
Autor(es): dc.creatorAquino, Ariana Musa-
Autor(es): dc.creatorValente, Leticia Cardoso-
Autor(es): dc.creatorKassuya, Cândida Aparecida Leite-
Autor(es): dc.creatorScarano, Wellerson Rodrigo-
Autor(es): dc.creatorArena, Arielle Cristina-
Data de aceite: dc.date.accessioned2025-08-21T21:53:14Z-
Data de disponibilização: dc.date.available2025-08-21T21:53:14Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.yrtph.2022.105302-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248072-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248072-
Descrição: dc.descriptionOndansetron is a 5HT3 receptor antagonist widely used to treat hyperemesis gravidarum, although its safety is still questionable. Since 5HT3 receptors, which are the target of this drug, can interfere with brain development through changes in neurotransmitter levels, this study evaluated whether the prenatal exposure to this drug could compromise reproductive and behavioral parameters in male offspring. Pregnant rats were treated with ondansetron (1.7 and 2.5 mg/kg/body weight; gavage), from gestational day 1–21. No exposure-related changes in clinical signs, body weight, food consumption, pregnancy length, and necropsy findings were observed in dams. Ondansetron exposure did not alter the anogenital distance or age of preputial separation in male offspring. Similarly, males exposed to therapeutic doses of ondansetron did not exhibit changes in play behavior. In adulthood, there were no changes in sperm parameters, as well as in testosterone level, sexual behavior and fertility. Furthermore, ondansetron did not interfere with testicular and epididymal histology, and with androgen receptor expression in hypothalamus. In conclusion, prenatal exposure to ondansetron did not cause maternal toxicity, as well as did not interfere with reproductive parameters of male offspring, indicating its safety after gestational exposure in rats.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionInstitute of Biosciences of Botucatu Department of Structural and Functional Biology University. Estadual Paulista – Botucatu (UNESP), São Paulo-
Descrição: dc.descriptionSchool of Health Sciences Federal University of Grande Dourados (UFGD), MS-
Descrição: dc.descriptionCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP), São Paulo State-
Descrição: dc.descriptionInstitute of Biosciences of Botucatu Department of Structural and Functional Biology University. Estadual Paulista – Botucatu (UNESP), São Paulo-
Descrição: dc.descriptionCenter of Toxicological Assistance (CEATOX) Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP), São Paulo State-
Descrição: dc.descriptionFAPESP: 2020/08745–9-
Idioma: dc.languageen-
Relação: dc.relationRegulatory Toxicology and Pharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject5HT3-
Palavras-chave: dc.subjectBrain sexual differentiation-
Palavras-chave: dc.subjectHyperemesis gravidarum-
Palavras-chave: dc.subjectMale rats-
Palavras-chave: dc.subjectPregnancy-
Título: dc.titleSafety evaluation of ondansetron after gestational exposure on male reproductive parameters in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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