Piperine-loaded nanoparticles incorporated into hyaluronic acid/sodium alginate-based membranes for the treatment of inflammatory skin diseases

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorPoliti, Flávio Augusto Sanches-
Autor(es): dc.creatorCarvalho, Suzana Gonçalves-
Autor(es): dc.creatorRodero, Camila Fernanda-
Autor(es): dc.creatordos Santos, Kaio Pini-
Autor(es): dc.creatorMeneguin, Andréia Bagliotti-
Autor(es): dc.creatorSorrechia, Rodrigo-
Autor(es): dc.creatorChiavacci, Leila Aparecida-
Autor(es): dc.creatorChorilli, Marlus-
Data de aceite: dc.date.accessioned2025-08-21T23:13:52Z-
Data de disponibilização: dc.date.available2025-08-21T23:13:52Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2022.12.147-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248069-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248069-
Descrição: dc.descriptionPiperine is an alkaloid mostly found in the fruits of several species of the Piper genus, and its anti-inflammatory potential is already known. However, its therapeutic applications still need to be better explored due to the low aqueous solubility of this active. To overcome this drawback, the objective of this work was to evaluate the efficiency of the nanoencapsulation of the compound as well as its incorporation into hyaluronic acid/alginate-based biomembranes. Polymeric nanoparticles composed of Eudragit S100 and Poloxamer 188 were obtained by the nanoprecipitation technique, obtaining spherical nanosized particles with an average diameter of 122.1 ± 2.0 nm, polydispersity index of 0.266, and encapsulation efficiency of 76.2 %. Hyaluronic acid/sodium alginate membranes were then prepared and characterized. Regarding permeation, a slow passage rate was observed until the initial 14 h, when an exponential increase in the recovered drug concentration began to occur. The in vivo assay showed a reduction in inflammation up to 43.6 %, and no cytotoxicity was observed. The results suggested the potential of the system developed for the treatment of inflammatory skin diseases.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Drugs and Medicines School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionCNPq: 140503/2019-6-
Descrição: dc.descriptionFAPESP: 2014/50928-2-
Descrição: dc.descriptionFAPESP: 2019/10761-5-
Descrição: dc.descriptionCNPq: 465687/2014-8-
Formato: dc.format736-748-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Biological Macromolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEudragit® S100-
Palavras-chave: dc.subjectHyaluronic acid-
Palavras-chave: dc.subjectSodium alginate-
Título: dc.titlePiperine-loaded nanoparticles incorporated into hyaluronic acid/sodium alginate-based membranes for the treatment of inflammatory skin diseases-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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