The Effect of Limosilactobacillus reuteri on Social Behavior Is Independent of the Adaptive Immune System

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Autor(es): dc.contributorBaylor College of Medicine-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDooling, Sean W.-
Autor(es): dc.creatorSgritta, Martina-
Autor(es): dc.creatorWang, I-Ching-
Autor(es): dc.creatorDuque, Ana Luiza Rocha Faria-
Autor(es): dc.creatorCosta-Mattioli, Mauro-
Data de aceite: dc.date.accessioned2025-08-21T17:36:08Z-
Data de disponibilização: dc.date.available2025-08-21T17:36:08Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1128/msystems.00358-22-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248058-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248058-
Descrição: dc.descriptionGut microbes can modulate almost all aspects of host physiology throughout life. As a result, specific microbial interventions are attracting considerable attention as potential therapeutic strategies for treating a variety of conditions. Nonetheless, little is known about the mechanisms through which many of these microbes work. Recently, we and others have found that the commensal bacterium Limosilactobacillus reuteri (formerly Lactobacillus reuteri) reverses social deficits in several mouse models (genetic, environmental, and idiopathic) for neurodevelopmental disorders in a vagus nerve-, oxytocin-, and biopterin-dependent manner. Given that gut microbes can signal to the brain through the immune system and L. reuteri promotes wound healing via the adaptive immune response, we sought to determine whether the prosocial effect mediated by L. reuteri also depends on adaptive immunity. Here, we found that the effects of L. reuteri on social behavior and related changes in synaptic function are independent of the mature adaptive immune system. Interestingly, these findings indicate that the same microbe (L. reuteri) can affect different host phenotypes through distinct mechanisms.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionNational Institutes of Health-
Descrição: dc.descriptionDepartment of Neuroscience Baylor College of Medicine-
Descrição: dc.descriptionMemory and Brain Research Center Baylor College of Medicine-
Descrição: dc.descriptionDepartment of Molecular and Human Genetics Baylor College of Medicine-
Descrição: dc.descriptionDepartment of Food and Nutrition School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Food and Nutrition School of Pharmaceutical Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2018/26645-1-
Descrição: dc.descriptionNational Institutes of Health: R01MH112356-01-
Idioma: dc.languageen-
Relação: dc.relationmSystems-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectadaptive immune system-
Palavras-chave: dc.subjectgut-microbiota-brain axis-
Palavras-chave: dc.subjectLactobacillus reuteri-
Palavras-chave: dc.subjectLimosilactobacillus reuteri-
Palavras-chave: dc.subjectoxytocin-
Palavras-chave: dc.subjectsocial behavior-
Título: dc.titleThe Effect of Limosilactobacillus reuteri on Social Behavior Is Independent of the Adaptive Immune System-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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