Asymptomatic HIV-Infected Patients Present Blood Parameters Changed, According to Use of Therapy and the CD4+ T Cells Count

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorTasca, Karen Ingrid-
Autor(es): dc.creatorde Souza, Lenice Do Rosário-
Data de aceite: dc.date.accessioned2025-08-21T22:28:12Z-
Data de disponibilização: dc.date.available2025-08-21T22:28:12Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/s2175-97902022e20808-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/248046-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/248046-
Descrição: dc.descriptionIn HIV-patients, the imbalance in immunological, hematological and biochemical factors can contribute to the progression to AIDS and non-AIDS comorbidities, even during combined antiretroviral therapy (cART). In this cross-sectional study, we aimed to analyze some of these parameters in 138 different asymptomatic HIV-infected patients, doing multiple comparisons between the groups, which are dichotomized in the presence/absence of cART and type of immune response (immunological responders [iR,>500cells/mL] or non-responders [iNR,<500cells/ mL]). Were analyzed cytokines and other routine laboratory parameters. Our results showed high creatine phosphokinase and low IL-10 levels in cART-patients. They also presented metabolic alterations, including elevations in total cholesterol and triglycerides, particularly in those iNR. In ART-iR an increased alanine aminotransferase was observed. Those NAÏVE-iNR presented high LDL-cholesterol, C-reactive protein and lactate dehydrogenase values. The long-term non-progressors (LTNP) showed the best laboratory results. In conclusion, many blood parameters were changed in HIV-patients, especially in those under cART. To identify LTNP individuals could be important to discussions their early therapeutic onset.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniversidade Estadual Paulista-
Descrição: dc.descriptionDepartment of Tropical Diseases Botucatu Medical School Universidade Estadual Paulista/UNESP, São Paulo-
Descrição: dc.descriptionDepartment of Tropical Diseases Botucatu Medical School Universidade Estadual Paulista/UNESP, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Pharmaceutical Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntiretroviral therapy-
Palavras-chave: dc.subjectBiochemical exams-
Palavras-chave: dc.subjectHematological exams-
Palavras-chave: dc.subjectHIV/AIDS-
Palavras-chave: dc.subjectMetabolic alterations-
Palavras-chave: dc.subjectMetabolic dysfunctions-
Título: dc.titleAsymptomatic HIV-Infected Patients Present Blood Parameters Changed, According to Use of Therapy and the CD4+ T Cells Count-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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